FACTOR IX

Factor IX is a clotting factor in the blood that depends on vitamin K for its function. It can be synthetically created from human plasma or produced by recombinant DNA technology. It is activated by factor XIa and by factor VII/tissue factor, leading to the convertion of factor X to Xa, to convert factor II (prothrombin) to thrombin that leads to the formation of a fibrin clot.

Uses

Factor IX is used in the following conditions:

  • Haemophilia B
  • Haemorrhage

Warnings

Factor IX should not be given in those with the following conditions:

  • Hypersensitivity to factor IX or hamster protein
  • Disseminated intravascular coagulation
  • Signs of fibrinolysis

Side Effects

Factor IX may have the following side effects:

  • Disseminated intravascular coagulation
  • Thromboembolism
  • Hypotension
  • Bronchospastic reactions
  • Nephrotic syndrome
  • Antibody formation
  • Headache
  • Dizziness
  • Drowsiness
  • Nausea
  • Vomiting
  • Dysgeusia
  • Difficulty of breathing
  • Hives, rash, urticaria
  • Fever, chills
  • Lethargy
  • Flushing
  • Pain
  • Stinging or burning at injection site
  • Anaphylaxis

Precautions

Precautions

Take extra caution in patients with the following conditions:

  • Thromboembolism
  • Disseminated intravascular coagulation (DIC)
  • Liver problems
  • Children
  • Pregnancy and lactation

 

Interactions

Factor IX may interact with Aminocaproic Acid

Overdose & Brands

If you think you may have overdosed, seek medical help immediately.

 

Available Brand:

  • Benefix

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