COMMON BRAND NAME(S): Myambutol
GENERIC NAME(S): ETHAMBUTOL HCL
Description: Ethambutol appears to stop substances of the bacteria needed in order to multiply. It is active against susceptible bacteria only when they are undergoing cell division.
Absorption: 80% is absorbed from the GI tract. Time to peak plasma concentration: W/in 4 hr.
Distribution: Distributed in most tissues, including lungs, kidneys, erythrocytes. Approx 10-50% may diffuse into CSF when meninges are inflamed. Crosses the placenta and enters breast milk.
Metabolism: Undergoes partial hepatic metabolism;, converted to the aldehyde and dicarboxylic acid derivatives (inactive).
Excretion: Via urine (as unchanged drug, 8-15% as metabolites) and faeces (20% as unchanged drug). Elimination half-life: Approx 3-4 hr.