Ertugliflozin is a dominant, specific, and transient blocker of sodium-glucose co-transporter 2 (SGLT2), the major carrier in the kidney’s adjacent complex tubules accountable for processed glucose reuptake. Suppressing SGLT2 lowers the barrier for glucose in the kidneys and stops the kidneys from reabsorbing processed glucose. This makes more glucose leave the body through urine and lowers blood sugar levels.

Sitagliptin works by suppressing the protein dipeptidyl peptidase-4 (DPP-4) and leading to increased quantities of functional internal secretion. Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are internal secretion phytohormones that control glycemic control by boosting adrenaline production and secretion from peripheral cells while decreasing glucagon production. Reduced glucagon secretion results to a decrease in the production of hepatic glucose.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Ertugliflozin + Sitagliptin is used in the following conditions:

  • Diabetes mellitus (Type 2)

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Ertugliflozin + Sitagliptin in people with the following conditions:

  • Renal dysfunction
  • Hemodialysis patients or those with ESRD

Ertugliflozin + Sitagliptin may have the following side effects:

  • Vulvovaginitis
  • Volume reduction
  • Mutilation of the lower limb
  • Acute kidney damage
  • Reduced eGFR
  • Elevated creatinine levels in the blood
  • Heart problems
  • Stiffness
  • Stomatitis
  • Diarrhea
  • Higher Hb
  • BUN
  • Severe UTI
  • Vomiting
  • Hepatic enzymes
  • Hypoglycemia
  • Serum lipid changes
  • Weight reduction
  • Candidal balanitis
  • Dehydration
  • Back ache
  • Myalgia
  • Rhabdomyolysis
  • Severe pain
  • Migraine
  • Vertigo
  • Frequent urination
  • Elevated LDL-cholesterol (LDL-C)
  • Vulvovaginal pruritus
  • Upper respiratory tract infection
  • Nasopharyngitis
  • Symptomatic low blood pressure
  • Balanoposthitis
  • Pruritus
  • Vulvovaginal candidiasis

Potentially Fatal: 

  • Necrotising pancreatitis
  • Angioedema
  • Acute pancreatitis, such as haemorrhagic
  • Diabetic ketoacidosis
  • Anaphylaxis
  • Necrotising fasciitis of the perineum
  • Stevens-Johnson syndrome

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects. 

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • CV disorder
  • Record of genital mycotic illnesses
  • Acute febrile disease
  • Volume reduction
  • Low blood pressure
  • Diabetic foot ulcers
  • Insufficient in pancreatic insulin 
  • Caloric restriction
  • Pancreatitis
  • Alcohol abuse
  • Renal (eGFR 45-<60 mL/min/1.73 m2) 
  • Dehydration
  • Pancreatic surgery
  • CHF
  • Angioedema with other DPP-4 inhibitor
  • Undertaking surgery such as bariatric procedures
  • Peripheral vascular disease
  • Neuropathy
  • Lactation
  • Hypovolemia
  • Chronic kidney insufficiency
  • Uncircumcised men
  • Diabetes mellitus (Type 1) 
  • Serious hepatic failure
  • Elderly
  • Maternity
  • Discontinue treatment for ≥4 days prior to surgery or any activity that might cause ketoacidosis

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Ertugliflozin + Sitagliptin may interact with the following medicines:

  • Digoxin levels in the blood
  • Diuretics
  • Diuretics

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you sense an overdose, contact your medical practitioner right away.

Available Brands:

  • Steglujan

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