Eculizumab is a drug that is also known as a recombinant monoclonal antibody. This drug binds with complement protein C5 and further prevents cleavage into C5a and C5b which subsequently inhibits the formation of terminal complex C5b-9. This leads to inhibit complement-mediated intravascular haemolysis and thrombotic microangiopathy.

Eculizumab is used in the following medical conditions:

  • Paroxysmal nocturnal haemoglobinuria
  • Haemolytic uraemic syndrome

Eculizumab should not be given to people with the following conditions:

  • Hypersensitivity
  • Unvaccinated against or unresolved N. meningitidis infection

Eculizumab may have some side effects, which includes the following:

  • Susceptibility to infections (e.g. pneumonia)
  • Infusion reactions/immunogenicity (e.g. hypersensitivity reactions, anaphylaxis)
  • Headache
  • Dizziness
  • Dysgeusia
  • Tremor
  • Insomnia
  • Fatigue
  • Influenza-like illness
  • Asthenia
  • Hypertension
  • Peripheral oedema
  • Tachycardia
  • Hypotension
  • Diarrhoea
  • Vomiting
  • Nausea
  • Abdominal pain
  • Gastroenteritis
  • Dyspepsia
  • Constipation
  • Cough
  • Oropharyngeal pain
  • Pneumonia
  • Nasopharyngitis
  • Upper respiratory tract infection
  • Nasal congestion
  • Bronchitis
  • Sinusitis
  • UTI
  • Uropathy
  • Proteinuria
  • Renal insufficiency
  • Leucopenia
  • Anaemia
  • Arthralgia
  • Myalgia
  • Pain in extremity
  • Back pain
  • Muscle spasm
  • Limb pain
  • Eye disorder
  • Rash
  • Pruritus
  • Alopecia
  • Herpes simplex infection
  • Neoplasms
  • Pyrexia
  • Chills
  • Hypokalaemia
  • Meningococcal infection


Take extra caution in people with the following medical conditions:

  • Active systemic infections
  • Haemolytic uraemic syndrome associated w/ Shiga toxin producing E. coli
  • Children
  • Pregnancy and lactation

People should get vaccination against N. meningitidis infections at least 2 weeks prior to starting treatment.



Concurrent admin of live vaccines may increase the risk of secondary transmission of infection.

If you think you have overdosed on Eculizumab, seek emergency medical treatment immediately.


Available Brand:

  • Soliris

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