Drotrecogin alfa (activated) is a human recombinant activated protein C. It is the first drug approved for the treatment of sepsis and known to have antithrombotic, anti-inflammatory and pro fibrinolytic activities.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully. 

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages. 

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day. 

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions. 

If you have any inquiries with regards to information, ask your physician or pharmacist. 

Drotrecogin alfa (activated) is used in the following conditions:

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Drotrecogin alfa (activated) in people with the following conditions:

  • Active internal bleeding
  • Patients with intracranial neoplasm
  • Mass lesion or cerebral herniation
  • Patients at increased risk of bleeding including major surgery
  • Recent (within 2 months) severe head trauma
  • Intracranial or intraspinal surgery
  • Haemorrhagic stroke within 3 mth
  • History of intracerebral aneurysm or CNS mass lesion
  • Presence of epidural catheter
  • Congenital bleeding diathesis
  • GI bleeding
  • Trauma with increased risk of life-threatening bleeding
  • Hypersensitivity

Drotrecogin alfa (activated) may have the following side effects:

  • Bruising
  • GI bleeding
  • Skin/soft tissue bleeding
  • Immune reaction
  • Retroperitoneal bleeding
  • Genitourinary bleeding
  • Intracranial bleeding
  • Intrathoracic haemorrhage.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing. 

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.


Take extra caution in patients with the following medical conditions:

  • Intracranial arteriovenous malformation or aneurysm. 
  • Known bleeding diathesis
  • Chronic severe hepatic disease. 
  • Any other condition in which bleeding may pose a significant hazard or would be difficult to manage because of its location. 
  • Stop infusion immediately if any clinically important bleeding occurs; may consider continued use if adequate haemostasis is achieved. 
  • Pregnancy and lactation. 


Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.



Drotrecogin alfa (activated) may interact with the following medicines:

  • Ibritumomab or prostacyclin
  • NSAIDs and pentosan polysulfate sodium 
  • Salicylates 
  • Tositumomab and iodine I 131 tositumomab.
  • Antiplatelet agents
  • Antithrombin III
  • Danaparoid
  • Fondaparinux
  • Heparin
  • Warfarin

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins. 

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details. 

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking. 

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice. 

Overdose & Brands

If an overdose is suspected call your healthcare provider immediately.

Available Brands:

  • Xigris
  • Xigris 20mg
  • Xigris vial

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