DROTRECOGIN ALFA (ACTIVATED)

Drotrecogin alfa (activated) is a human recombinant activated protein C. It is the first drug approved for the treatment of sepsis and known to have antithrombotic, anti-inflammatory and pro fibrinolytic activities.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Uses

Drotrecogin alfa (activated) is used in the following conditions:

Severe sepsis

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Drotrecogin alfa (activated) in people with the following conditions:

Active internal bleeding
Patients with intracranial neoplasm
Mass lesion or cerebral herniation
Patients at increased risk of bleeding including major surgery
Recent (within 2 months) severe head trauma
Intracranial or intraspinal surgery
Haemorrhagic stroke within 3 mth
History of intracerebral aneurysm or CNS mass lesion
Presence of epidural catheter
Congenital bleeding diathesis
GI bleeding
Trauma with increased risk of life-threatening bleeding
Hypersensitivity

Side Effects

Drotrecogin alfa (activated) may have the following side effects:

Bruising
GI bleeding
Skin/soft tissue bleeding
Immune reaction
Retroperitoneal bleeding
Genitourinary bleeding
Intracranial bleeding
Intrathoracic haemorrhage.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

Intracranial arteriovenous malformation or aneurysm.
Known bleeding diathesis
Chronic severe hepatic disease.
Any other condition in which bleeding may pose a significant hazard or would be difficult to manage because of its location.
Stop infusion immediately if any clinically important bleeding occurs; may consider continued use if adequate haemostasis is achieved.
Pregnancy and lactation.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Drotrecogin alfa (activated) may interact with the following medicines:

Ibritumomab or prostacyclin
NSAIDs and pentosan polysulfate sodium
Salicylates
Tositumomab and iodine I 131 tositumomab.
Antiplatelet agents
Antithrombin III
Danaparoid
Fondaparinux
Heparin
Warfarin

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

If an overdose is suspected call your healthcare provider immediately.

Available Brands:

Xigris
Xigris 20mg
Xigris vial