Dorzolamide reversibly suppresses carbonic anhydrase in the ciliary processes of the eye, leading in decreased generation of bicarbonate ions and concomitant reduction in Na and fluid transport, hence, reducing aqueous humor production and intraocular pressure.

Timolol is a non-selective β-adrenergic receptor antagonist. Although the specific method by which it reduces intraocular pressure has not been determined, it is speculated that its primary activity may be linked to lowering aqueous humor production or, more likely, improving aqueous humor outflow.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Dorzolamide + Timolol is used in the following conditions:

  • Open-angle glaucoma
  • Ocular hypertension
  • Pseudoexfoliation glaucoma

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Dorzolamide + Timolol in people with the following conditions:

  • Sick sinus syndrome
  • Sino-atrial block
  • Existing or history of bronchial asthma
  • 2nd- or 3rd-degree atrioventricular block
  • Severe COPD
  • Sinus bradycardia
  • Overt cardiac failure
  • Cardiogenic shock

Dorzolamide + Timolol may have the following side effects:

  • Choroidal detachment 
  • Corneal edema
  • Lid reactions
  • Conjunctivitis
  • Dry eyes
  • Angioedema
  • Irreversible corneal decompensation 
  • Pruritus
  • Rash
  • Exacerbation of myasthenia gravis
  • Urolithiasis
  • Blurred vision
  • Corneal erosion
  • Iridocyclitis
  • Sinusitis
  • Contact dermatitis
  • Syncope
  • Dyspnea
  • Bacterial keratitis
  • Urticaria
  • Stinging
  • Itching
  • Anaphylaxis
  • Bradycardia
  • Ocular burning
  • Tearing
  • Conjunctival hyperemia
  • Blepharitis
  • Dysgeusia
  • Nausea
  • Asthenia
  • Headache
  • Dizziness
  • Paraesthesia
  • Depression

Potentially Fatal: 

  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Bronchospasm (in patients with asthma)
  • Cardiac failure

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects. 

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • 1st-degree heart block
  • Atopy
  • Severe anaphylaxis to allergens
  • CV disease
  • Mild or moderate COPD
  • Labile diabetes 
  • Cerebrovascular insufficiency
  • Hyperchloremic acidosis
  • Severe forms of Raynaud’s disease
  • Spontaneous hypoglycemia
  • Hyperthyroidism
  • Corneal disease
  • Preexisting chronic corneal defects and/or history of intraocular surgery
  • Low endothelial cell counts
  • History of psychiatric illness
  • Avoid abrupt withdrawal
  • Myasthenia gravis
  • Renal calculi
  • Hepatic and mild to moderate renal impairment. 
  • Pregnancy
  • Lactation
  • Narrow-angle glaucoma
  • Severe renal impairment
  • Patients undergoing surgery 

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Dorzolamide + Timolol may interact with the following medicines:

  • Reserpine
  • Oral β-adrenergic blocking agents
  • Parasympathomimetics
  • Dorzolamide
  • Paroxetine
  • Fluoxetine
  • Epinephrine
  • Guanethidine
  • Narcotics
  • MAOIs
  • Timolol
  • Amiodarone
  • Digitalis glycosides
  • Quinidine
  • Antidiabetic agents

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Symptoms of overdose may include the following: 

  • Development of acidotic state
  • Possible CNS effects
  • Shortness of breath
  • Bradycardia
  • Dizziness
  • Headache
  • Bronchospasm
  • Cardiac arrest
  • Electrolyte imbalance

Seek medical help immediately.

Available Brands:

  • Zolichek-T
  • Cosopt

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