Dihydralazine is a direct-acting vasodilator that mainly affects the arterioles. It raises cardiac output by lowering blood pressure and peripheral resistance. It also improves renal and cerebral blood flow, with a stronger effect on diastolic pressure than systolic pressure.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Dihydralazine is used in the following conditions:

  • Hypertension

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information. 

Do not use Dihydralazine in people with the following conditions:

  • Severe tachycardia
  • Dissecting aortic aneurysm
  • Heart failure with high cardiac output
  • Cor pulmonale
  • Myocardial infarction due to mechanical obstruction
  • Idiopathic systemic lupus erythematosus (SLE) and related disorders
  • Porphyria
  • 1st 2 trimesters during pregnancy

Dihydralazine may have the following side effects:

  • Tachycardia
  • Palpitations
  • Angina pectoris
  • Severe headache
  • Gastrointestinal disturbances
  • Flushing
  • Dizziness
  • Nasal congestion
  • Postural hypotension
  • Fluid retention with edema and weight gain
  • Conjunctivitis
  • Lachrymation
  • Tremor
  • Peripheral neuropathy with numbness and tingling of extremities
  • Muscle cramps
  • Hepatotoxicity
  • Blood dyscrasias
  • Hemolytic anemia
  • Difficulty in urinating
  • Glomerulonephritis
  • Constipation
  • Paralytic ileus
  • Depression
  • Anxiety
  • Hypersensitivity reactions
  • Eosinophilia
  • A condition resembling systemic lupus erythematosus (SLE) with prolonged use of large doses

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Ischemic heart disease
  • Myocardial infarction
  • Cerebrovascular disorders
  • Renal or hepatic impairment
  • Monitor for postural hypotension and tachycardia during initial therapy if given to patients with heart failure
  • Gradual withdrawal is advisable

Prior in taking this medicine, tell your physician or pharmacist if you have allergies or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Dihydralazine may interact with the following medicines:

  • Agents with hypotensive action
  • Diazoxide
  • Thiazide diuretics

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If an overdose is suspected, call your health care provider immediately.

Available brands:

  • Apresoline

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