Description: Diflorasone diacetate is a corticosteroid that reduces the actions of chemicals in the body that cause inflammation, redness, and swelling.
Absorption: Percutaneous absorption is increased when the skin is inflammed or occlusive dressing is used.
Metabolism: Once absorbed systemically, it is metabolised hepatically.
Excretion: Once absorbed systemically, it is excreted renally.


Treating inflammation and itching due to certain skin conditions.

This is used for relief of the inflammatory and pruritic manifestations of dermatoses.


Should not be used in patients with hypersensitivity reactions from this drug.

Not available.

Common side effects persist or become bothersome:

  • dryness
  • itching

Seek medical attention right away if any of these SEVERE side effects occur:

  • severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest;
  • swelling of the mouth, face, lips, or tongue);
  • acne-like rash;
  • burning,
  • cracking,
  • irritation,
  • itching, or
  • peeling not present before you began using diflorasone diacetate cream;
  • excessive hair growth;
  • inflamed hair follicles;
  • inflammation around the mouth;
  • muscle weakness; thinning,
  • softening, or
  • discoloration of the skin;
  • unusual weight gain, especially in the face


  • Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria in some patients.
  • Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings.
  • Pediatric patients may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity.
  • If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted.
  • In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.

Pregnancy Risk: Category C. Topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.

Breastfeeding: Systemically administered corticosteroids are secreted into breast milk in quantities not likely to have a deleterious effect on the infant. Nevertheless, caution should be exercised when topical corticosteroids are administered to a nursing woman.


Some medicines may interact with diflorasone diacetate cream. Because little, if any, of diflorasone diacetate cream is absorbed into the blood, the risk of it interacting with another medicine is low.


This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room immediately.


Store diflorasone diacetate cream at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep diflorasone diacetate cream out of the reach of children and away from pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.


There are no brands containing this molecule.

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