DEFLAZACORT

Deflazacort is medicine that is known as a glucocorticoid derived from prednisolone. It has anti-inflammatory and immunosuppressive properties.

Uses

Deflazacort is used for treating allergic and inflammatory disorders.

Warnings

Deflazacort should not be given to people with systemic infections, those who just had live virus vaccines and those who just had immunosuppressive treatments.

Side Effects

Deflazacort may have the following side effects:

Weight gain
Hypothalamic-pituitary-adrenal (HPA) axis suppression
Amenorrhoea
Cushingoidfacies
Growth suppression (children)
Increased appetite
Opportunistic infections
Candidiasis
Osteoporosis
Myopathy
Menstrual irregularity
Heart failure
Headache
Vertigo
Restlessness
Depression
Labile mood
Irritability
Euphoria
Mania
Delusions
Hallucinations
Schizophrenia
Behavioural disturbances
Anxiety
Sleep disturbances
Cognitive dysfunction including confusion and amnesia
Increased intra-ocular pressure
Glaucoma
Chorioretinopathy
Corneal/scleral thinning
Posterior subcapsular cataract
Dyspepsia
Peptic ulceration
Haemorrhage
Nausea
Acute pancreatitis (children)
Hirsutism
Striae
Acne
Skin atrophy
Telangiectasia
Edema
Impaired healing
Leukocytosis
Rarely, muscle wasting, bruising, benign intracranial HTN

Precautions

Precautions

Take extra caution in patients with the following conditions:

Infection
History of TB
Cardiac disease or CHF (except in the presence of active rheumatic carditis)
HTN
Thromboembolic disorders
GI disorders (i.e. gastritis, diverticulitis, ulcerative colitis, peptic ulcer, pyogenic infections)
DM (including family history)
Osteoporosis
Myasthenia gravis
Epilepsy
Emotional instability
History of corticosteroid-induced myopathy
Hypothyroidism
Ocular herpes simplex
Renal and hepatic (including hepatic failure and cirrhosis) impairment
Children
Pregnancy and lactation

Interactions

Deflazacort may interact with the following medicines:

Hepatic enzyme inducers (e.g. rifampicin, rifabutin, carbamazepine, phenobarbitone, phenytoin, primidone, aminoglutethimide)
Hepatic enzyme inhibitors (e.g. ketoconazole)
Hypoglycaemic agents
Antihypertensives
Diuretics
Acetazolamide
Loop/thiazide diuretics
β2-agonists
Xanthines
Carbenoxolone
Coumarins
Non-depolarising muscle relaxants
Salicylates
Oral contraceptives
Quinolones

Overdose & Brands

If you think you have overdosed with deflacort, seek emergency medical treatment immediately.

Available Brand:

Emflaza