Description: Danazol is a man-made steroid that reduces the release of follicle-stimulating hormone and luteinizing hormone. This causes the thinning endometrial tissue, decreases growth rate of abnormal breast tissue and reduces attacks in hereditary angioedema.
Onset: Approximately 4 wk.
Absorption: Absorbed from the GI tract (oral); absorption increases if taken with food.
Metabolism: Hepatic (extensive); converted to 2-hydroxymethylethisterone.
Excretion: Via the urine.


This medication is used in women to treat pelvic pain and infertility due to a certain uterus disorder (endometriosis) and also to treat breast pain/tenderness/nodules due to a certain breast condition (fibrocystic breast disease).

It is also used in both men and women to prevent swelling of the abdomen/arms/legs/face/airway due to a certain congenital disease (hereditary angioedema).


Should not be given to patients with:

  • Undiagnosed abnormal genital bleeding
  • Markedly impaired hepatic, renal, or cardiac function
  • Pregnancy
  • Breast feeding

How to use danazol:


Endometriosis: 100 to 200 mg orally twice a day

Fibrocystic Breast disease: 50 to 200 mg orally twice daily

Angioedema: 200 mg orally two to three times daily

  • Take this medication by mouth, usually twice daily or as directed by your doctor.
  • You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Blood disorder: This medication may often cause serious blood disorders, such as anemia, lower your body’s ability to fight an infection, and increase your risk of bleeding.

Liver problems: Dacarbazine may also cause rare but serious liver problems. These side effects may rarely be life-threatening. Your doctor will monitor you closely while you are receiving this medication.

Common side effects:

  • Nausea,
  • vomiting, and
  • loss of appetite

Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

If this medication leaks out of the vein into the tissue under the skin, it may cause serious tissue damage. Tell your doctor immediately if you experience pain, burning, redness, or swelling at the injection site.

Tell your doctor right away if you have any serious side effects, including: mouth sores, confusion, seizures, sunburn (sun sensitivity).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.


  • Allergy: Before taking danazol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
  • Medical History: Before using this medication, tell your doctor or pharmacist if you had: heart/blood vessel disease (such as coronary artery disease, stroke), high blood pressure (hypertension), diabetes, high cholesterol levels, breast cancer, liver disease, kidney disease, seizures, migraine headaches, unusual vaginal bleeding, certain blood disorders (porphyria, polycythemia), prostate cancer.
  • Infertility: This medication may affect the sperm.

Pregnancy Risk:  Category X. This medication must not be used during pregnancy. It may harm the unborn baby.

Breastfeeding: It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended.


Some products that may interact with this drug include: “blood thinners” (such as warfarin), carbamazepine, certain “statin” cholesterol medications (lovastatin, simvastatin), cyclosporine, tacrolimus.


If overdose is suspected, contact a poison control center or emergency room immediately.Symptoms of overdose may include: yellowing eyes/skin, severe stomach/abdominal pain, dark urine.


Do not share this medication with others.

Laboratory and/or medical tests (such as liver function, cholesterol levels) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.


Available Brands

  • Ladogal [ sanofi-aventis ]

Also marketed as

  • Elle [ Korea United Pharma ]

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