COMMON BRAND NAME(S): DTIC-Dome
GENERIC NAME(S): DACARBAZINE
Description: Dacarbazine is a cancer medication under the alkylating agent group. It appears to form methylcarbonium ions that attack nucleophilic groups. It also cross-links DNA strands leading to inhibition of DNA, RNA and protein synthesis. This interferes in the growth in cancer cells and can eventually kill it.
Absorption: Poorly absorbed from the GI tract (oral).
Distribution: Crosses the blood-brain barrier; localised in the liver. Protein-binding: 5%.
Metabolism: Extensively hepatic.
Excretion: Urine (as unchanged drug). Elimination half-life: 20 min (initial), 5 hr (terminal).