Cladribine is a purine nucleoside analogue that acts as an antimetabolite, a prodrug that is activated by phosphorylation and transformed to cladribine triphosphate or Cd-ATP (active metabolite). Cd-ATP suppresses ribonucleotide reductase and binds to DNA strands, disrupting repair and DNA synthesis. Its method of action in the therapy of multiple sclerosis is unknown; however, it is suspected to entail cytotoxic effects on B and T cells through DNA synthesis impairment, resulting in lymphocyte depletion.
Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.
The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.
If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.
Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.
If you have any inquiries with regards to information, ask your physician or pharmacist.
