CISPLATIN - Watsons Health

CISPLATIN

COMMON BRAND NAME(S): Platinol-AQ

GENERIC NAME(S): CISPLATIN
Description: Cisplatin modifies cell cycle by interfering with DNA structure and function. This results in a disrupted cell growth of cancer cells Cisplatin synergises with other anticancer drugs e.g. fluorouracil. It has a narrow therapeutic margin and is highly toxic.

Pharmacokinetics:

Absorption: Well absorbed (intraperitoneal).

Distribution: Concentrated in the liver, kidneys, large and small intestines; poor penetration into the CNS.

Excretion: Urine. Elimination half-life: 25-49 min (initial), 58-73 hr (terminal).

Cisplatin, a chemotherapy drug that contains platinum, treats various types of cancer whether used alone or in combination with other medications to slow or stop cancer cell growth.

How to use cisplatin intravenous

This medication is usually given by injection into a vein by a health care professional. The dosage is based on your medical condition, body size, and response to therapy. Courses of cisplatin treatment should not be given more often than once every 3 to 4 weeks. Consult your doctor or pharmacist for more details.

During treatment with this medication, it is important that you take in more fluids than usual and pass urine frequently to help avoid kidney side effects. Intravenous fluids should be given with this medication. Also, ask your doctor how much fluid you should drink and follow these instructions carefully.

If this medication comes into contact with your skin, wash your skin immediately and completely with soap and water.

Cisplatin may cause severe kidney problems or very serious allergic reactions. Hearing loss (more common in children), bleeding problems, a decrease in your body’s ability to fight infections (bone marrow suppression), and severe nausea and vomiting may occur as well. Your risk of these problems increases with higher doses or longer treatment with cisplatin.

Notify your doctor or pharmacist promptly if any of these effects persist or worsen:

  • Nausea
  • Vomiting
  • loss of appetite
  • diarrhea
  • loss of taste

Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

Tell your doctor right away if you have any serious side effects, including:

  • pain/burning/redness at the injection site
  • numbness/tingling/coldness/blue discoloration of the hands or feet
  • pain/redness/swelling of arms or legs
  • loss of reflexes
  • loss of balance
  • trouble walking
  • muscle cramps/spasms/weakness
  • neck or back pain
  • mouth or tongue sores
  • joint pain
  • swollen legs or feet
  • mental/mood changes
  • headache
  • fast/irregular heartbeat
  • blood in urine
  • vomit that looks like coffee grounds
  • black or bloody stools
  • painful or difficult urination
  • lower back or side pain
  • vision changes (e.g., blurred vision, seeing colors differently)

Rarely, temporary vision loss may occur with cisplatin use. Normal vision usually returns after the end of treatment.

Get medical help right away if you have any very serious side effects, including:

  • chest pain
  • jaw or left arm pain
  • confusion
  • slurred speech
  • weakness on one side of the body
  • seizures

This medication can lower your body’s ability to fight an infection.

A very serious allergic reaction to this drug is rare.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Consult your doctor regarding these precautions:

  • Allergic reaction to this medication.
  • Patients with medical history of:
    • kidney disease
    • decreased bone marrow function/blood cell disorders (e.g., anemia, leukopenia, thrombocytopenia)
    • hearing problems
    • mineral imbalance (low blood levels of sodium, potassium, magnesium, calcium, phosphate)
    • numbness/tingling of the hands/feet
    • kidney stones
    • gout
  • Do not have immunizations/vaccinations without the consent of your doctor.
  • Avoid contact with people who have recently received oral polio vaccine.
  • Elderly because they may be more sensitive to kidney problems, numbness/tingling of the hands/feet, infections, and bleeding problems.
  • Caution is advised when using this drug in children because they may be more sensitive to hearing loss.
  • This drug is not recommended for use during pregnancy.
  • Consult your doctor before breast-feeding.
  • This medication can affect sperm production in men.

 

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions.

Some products that may interact with this drug include:

  • aminoglycoside antibiotics (e.g., gentamicin, neomycin)
  • amphotericin B
  • anti-seizure medications (e.g., phenytoin)
  • certain “water pills” (loop diuretics such as furosemide, bumetanide, ethacrynic acid)
  • nalidixic acid
  • pyridoxine when used in combination with both altretamine and cisplatin

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately.

Notes

Laboratory and/or medical tests (e.g., kidney function tests, complete blood count, blood mineral levels, hearing tests) should be performed to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule.

Storage

Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

 

Brands:
Available Brands

Cisteen [ Ambica ] Cysplack [ Pascual ]
Cytosplat [ Korea United Pharma ] Kemoplat [ Fresenius Kabi ]
Platin [ Intas ]

Also marketed as

Docistin LPFI [ Biomedis Oncology ] Oncotin [ Cipla ]
Placitin [ Pharmedic Lab ] Platinol [ Bristol-Myers Squibb ]

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