CHRONIC GLOMERULONEPHRITIS

Chronic glomerulonephritis is a long-term condition characterized by inflammation and damage to the glomeruli, the tiny filtering units in the kidneys responsible for removing waste and excess fluids from the blood. Over time, chronic inflammation of the glomeruli can lead to progressive scarring (glomerulosclerosis) and impairment of kidney function. Chronic glomerulonephritis is a leading cause of chronic kidney disease (CKD) and can eventually result in end-stage renal disease (ESRD), requiring dialysis or kidney transplantation for survival.

SYMPTOMS

Chronic glomerulonephritis often progresses slowly over months or years and may not cause noticeable symptoms in the early stages. However, as kidney function declines, symptoms may develop and may include:

  • Swelling (edema) in the face, hands, feet, or abdomen
  • Foamy or bubbly urine (indicative of proteinuria)
  • Blood in the urine (hematuria)
  • High blood pressure (hypertension)
  • Fatigue
  • Decreased urine output
  • Increased frequency of urination, particularly at night
  • Loss of appetite
  • Nausea and vomiting
  • Itching or skin rashes (uremic pruritus)

DIAGNOSIS

Diagnosing chronic glomerulonephritis typically involves a combination of medical history, physical examination, and diagnostic tests, including:

  • Urinalysis: Urine testing to assess for the presence of protein, blood, or other abnormalities.
  • Blood tests: Blood tests to measure kidney function, electrolyte levels, and markers of inflammation (such as C-reactive protein).
  • Kidney imaging: Imaging tests such as ultrasound, CT scan, or MRI may be performed to assess the size, shape, and structure of the kidneys.
  • Kidney biopsy: A kidney biopsy may be performed to obtain a tissue sample for microscopic examination, which can help determine the underlying cause and severity of glomerular damage.

TREATMENT

Treatment of chronic glomerulonephritis aims to slow the progression of kidney damage, manage symptoms, and prevent complications. Treatment options may include:

  • Medications: Depending on the underlying cause and specific symptoms, medications such as angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), diuretics, or immunosuppressive agents may be prescribed.
  • Blood pressure management: Controlling high blood pressure is crucial in managing chronic glomerulonephritis and reducing the risk of further kidney damage. Lifestyle modifications and antihypertensive medications may be recommended.
  • Dietary modifications: Limiting sodium, protein, and phosphorus intake may help reduce fluid retention, proteinuria, and electrolyte imbalances associated with chronic kidney disease.
  • Dialysis: In advanced stages of chronic glomerulonephritis, when kidney function is severely impaired, dialysis may be necessary to remove waste products and excess fluids from the blood.
  • Kidney transplantation: For individuals with end-stage renal disease, kidney transplantation offers the best long-term outcome and quality of life.

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