Chlorambucil is a nitrogen mustard alkylating agent, which is derived from chlormethine, that acts by interfering with DNA replication and RNA transcription by alkylation and cross-linking the cellular DNA strands, thereby resulting in disruption of the nucleic acid function and cell death.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Chlorambucil is used in the following conditions:

  • Hodgkin’s disease
  • Non-Hodgkin’s lymphoma
  • Chronic lymphocytic leukemia
  • Waldenstrom’s macroglobulinemia

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Chlorambucil in people with the following conditions:

Chlorambucil may have the following side effects:

  • Myelosuppresion
  • Infertility prepubertal/pubertal males
  • Azoospermia in adult males
  • Amenorrhea
  • Acute leukemia
  • Focal and/or generalised seizures (rare)
  • Erythema multiforme
  • Stevens Johnson syndrome
  • Toxic epidermal necrolysis
  • Peripheral neuropathy
  • Agitation
  • Ataxia
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Anorexia
  • Oral ulceration
  • Interstitial pneumonia
  • Hepatotoxicity
  • Jaundice
  • Sterile cystitis
  • Leucopenia
  • Thrombocytopenia
  • Anemia
  • Pancytopenia
  • Irreversible bone marrow failure
  • Rash
  • Urticarial
  • Angioedema
  • Dermatitis
  • Pruritus
  • Occurrence or exacerbation of herpes zoster
  • Hyperuricemia
  • Drug fever


Potentially Fatal:

  • Pulmonary fibrosis (rare)


Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Patient withhistory of seizure disorder or head trauma
  • Nephrotic syndrome
  • Receiving high-pulse therapy
  • Patient who has recently undergone radiotherapy or received other cytotoxic agents
  • Administration of live vaccines
  • Severe hepatic or renal impairment
  • Children
  • Elderly
  • Pregnancy

Prior in taking this medicine, tell your physician or pharmacist if you have allergies  or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.



Chlorambucil may interact with the following medicines:

  • Nalidixic acid

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you think you have used Chlorambucil more than the usual dosage, please seek medical help immediately.

Symptoms of overdose may include the following:

  • Reversible pancytopenia
  • Agitation
  • Ataxia
  • Multiple grand mal seizures


Available Brands:

  • Leukeran

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