Description: Cefazolin binds to 1 or more of the penicillin-binding proteins (PBPs) which stops the bacteria’s production of cell wall and kill it.

Cefazolin, a cephalosporin antibiotic, treats a wide variety of bacterial infections by stopping the growth of bacteria. It may also be used before and during certain surgeries to help prevent infection.

How to use cefazolin intravenous

Depending on your specific product, this medication is given by injection into a vein or into a muscle. Use this product exactly as directed by your doctor. The dosage is based on your medical condition and response to treatment.

If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, use this drug at evenly spaced intervals.

Continue to use this medication until the full prescribed treatment period is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition persists or worsens.

Tell your doctor or pharmacist promptly if any of these effects persist or worsen:

  • swelling
  • redness
  • pain
  • soreness at the injection site
  • loss of appetite
  • nausea
  • vomiting
  • diarrhea
  • headache

Tell your doctor right away if you have any serious side effects, including:

  • dark urine
  • easy bruising/bleeding
  • fast/pounding/irregular heartbeat
  • seizures
  • unusual weakness
  • yellowing eyes/skin
  • mental/mood changes (such as confusion)

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped.

Do not use anti-diarrhea products or narcotic pain medications if you have any of these symptoms because these products may make them worse.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection.

A very serious allergic reaction to this drug is rare.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.


  • Allergic reaction to this medication.
  • Patients with medical history of: kidney disease, liver disease, stomach/intestinal diseases (e.g., colitis).
  • Elderly people may be at greater risk for side effects while using this drug.
  • Tell your doctor if you are pregnant before using this medication.
  • Consult your doctor before breast-feeding.

Consult your doctor regarding the precautions mentioned above.



Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions.

Some products that may interact with this drug include:

  • aminoglycoside antibiotics (e.g., tobramycin, gentamicin)
  • “blood thinners” (e.g., warfarin)
  • chloramphenicol
  • live bacterial vaccines

Although most antibiotics probably do not affect hormonal birth control such as pills, patch, or ring, some antibiotics may decrease their effectiveness.

This medication may interfere with certain laboratory tests (including Coombs’ test), possibly causing false test results.


If overdose is suspected, contact a poison control center or emergency room immediately. Symptoms of overdose may include: trouble breathing, seizures.

Notes: Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in that case.

Laboratory and/or medical tests (e.g., complete blood count) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose: For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule. Do not double the dose to catch up.

Storage: Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.



Available brands

  • Cefavex [ NCPC ]
  • Cefazole [ Nutramedica ]
  • Cizo [ Bosch ]
  • Cloviz [ General Drugs House ]
  • Fazonil [ Singapore Pharmawealth Lifesciences ]
  • Fonvicol [ Panpharma-Meinz ]
  • Hazolin [ Harbin ]
  • Ilozef [ Shenzhen Pharma ]
  • Stancef [ Biomedis ]
  • Zofadep [ MJ Biopharm ]

Also marketed as

  • 2 World Cefazolin [ NingboTisun Medic ]
  • Biocef [ Pharmpartners ]
  • Cefazovit [ Pan-Ject Pharma ]
  • Cifoxim [ Taiwan Biotech ]
  • Fazol [ Aurobindo ]
  • Leklin [ Unique ]
  • Lozan [ Vysali ]  Maxcep [ Danlex ]
  • Novazef [ China Chemical & Pharma ]
  • Oryant [ CKD ]
  • Refzolin [ D. B. Manix ]
  • Suporin [ Umedica ]
  • Tefazol [ Shanxi Taisheng ]
  • Zolfas [ Syncom ]
  • Zolival [ Virgo ]

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