CARBOPLATIN

Carboplatin can cause severe blood disorders (e.g., anemia, bone marrow suppression) that can result in infection and bleeding problems.

Vomiting is a common side effect of this medication.

Notify your doctor or pharmacist promptly if any of these effects persist or worsen:

• stomach pain
• body aches/pain
• diarrhea
• constipation
• weakness
• nausea
• vomiting

Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

Tell your doctor right away if you have any serious side effects, including:

• numbness or tingling in the hands/feet
• mouth sores
• yellowing eyes/skin
• dark urine
• unusual tiredness
• change in the amount of urine
• pain/swelling/redness at the injection site
• hearing problems (e.g.,ringing in the ears, hearing loss)
• easy bruising/bleeding
• blood in the urine
• black/bloody stools
• fast/irregular heartbeat

Rarely, temporary vision loss may occur with high doses of carboplatin. Normal vision usually returns within several weeks after the end of treatment.

This medication can lower your body’s ability to fight an infection.

A very serious allergic reaction to this drug is unlikely.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

• Allergic reaction to this medication.
• Patients with decreased bone marrow function/bloodcell disorders (e.g., anemia, leukopenia, thrombocytopenia).
• Patients with medical history of kidney problems and mineral imbalance (lowblood levels of sodium, potassium, magnesium, calcium).
• Do not haveimmunizations/vaccinations without the consent of your doctor.
• Avoid contact with people who have recently received oralpolio
• The elderly may be more sensitive to bleeding problems and numbness/tingling of the hands/feet.
• Children may be at greater risk for hearing loss.
• This medication can affect sperm production in men.
• This medication is not recommended for use during pregnancy.
• Breast-feeding while using this drug is not recommended.

Consult your doctor regarding the precautions mentioned above.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions.

Some products that may interact with this drug include:

• aminoglycoside antibiotics (e.g., gentamicin, neomycin)
• amphotericin B
• certain anti-seizure medications (hydantoins such as phenytoin)
• certain “water pills” (loop diuretics such as furosemide, bumetanide, ethacrynic acid)
• nalidixic acid

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately.

Notes: Laboratory and/or medical tests (e.g., complete blood counts, kidney function tests, blood mineral levels) should be performed to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose: For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule.

Storage: Not applicable. This medication is given in a clinic and will not be stored at home.

Brands

Available Brands

• Actoplatin [ Actavis ]
• Biovinate [ Biomedis Oncology ]
• Carbosin [ Pharmachemie ]
• Carbotinol [ Korea United Pharma ]
• Kemocarb [ Fresenius Kabi ]
• Naproplat [ Ambica ]

Also marketed as

• Paraplatin [ Bristol-Myers Squibb ]