Canrenone is a specific antagonist of aldosterone that increases sodium and water excretion and reduces potassium excretion. As a competitive inhibitor of aldosterone, it inhibits the effects of aldosterone.

This drug is used to treat conditions like Hepatic diseases, Hypertension and Refractory oedema associated with heart failure.

Older patients and those who have renal or hepatic impairement, porphyria are likely to develop acidosis. Serum electrolytes and blood-urea-nitrogen level must be monitored while using this drug.

Side effects of Canrenone may include:

  • Headache
  • Drowsiness
  • Ataxia
  • Mental Confusion
  • Skin Rashes
  • Gynecomastia
  • Breast Enlargement
  • Hirsutism
  • Deepening of the Voice
  • Menstrual Irregularities
  • Impotence
  • Mild Acidosis

Notify your doctor promptly if any of these symptoms persist or worsen.

Your doctor may have prescribed this medication because he or she judged that the benefit to you is greater than the risk of side effects.

Possible fatal side effects may include:

  • Lethargy
  • Hyperkalaemia
  • Hyponatraemia
  • Hepatotoxicity
  • Osteomalacia
  • Blood Disorders

Seek immediate medical attention if you experience any of these serious side effects.


Before taking this drug, tell your doctor or pharmacist:

  • If you are allergic to it or if you have any other allergies.
  • If you are pregnant or breastfeeding.
  • If you are taking herbal, prescription and non-prescription drugs.
  • If you have certain medical conditions such as:
    • Hyperkalemia
    • Hyponatremia
    • Addison’s Disease
    • Severe Renal Impairment



Drug interactions may either lessen the effectiveness of this drug or heighten the risk for severe side effects. It’s important to inform your doctor all the medication including prescription and non-prescription and herbal medicines you are taking or going to take.

Possible interactions with this drug are:

  • Potassium Supplements
  • Other Potassium-Sparing Diuretics
  • ACE Inhibitors
  • Angiotensin II Receptor Antagonists
  • Trilostane
  • Lithium
  • Thiazides
  • Chlorpropamide
  • Other Antihypertensives
  • Noradrenaline
  • Carbenoxolone

Call emergency hotline if someone has overdosed and has serious symptoms such as passing out or trouble breathing.


Available brand/s:

  • Canrenone

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