HUMAN PAPILLOMAVIRUS 9-VALENT VACCINE

BLINATUMOMAB

Blinatumomab is a novel drug used as a treatment for late stage B cell malignancies. It moderates production of cytolytic proteins, liberation of inflammatory cytokines, and proliferation of T-cells, resulting in the lysis of CD 19 positive cells.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully. 

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages. 

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day. 

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions. 

If you have any inquiries with regards to information, ask your physician or pharmacist.

Blinatumomab is used in the following conditions:

  • Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia.

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.  

Do not use Blinatumomab in people with the following conditions:

  • Lactation

Blinatumomab may have the following side effects:

  • Anemia
  • Thrombocytopenia
  • Transient elevation in liver enzymes
  • Leukoencephalopathy
  • Progressive multifocal leukoencephalopathy
  • Disseminated intravascular coagulation
  • Capillary leak syndrome
  • Hemophagocytic histiocytosis or macrophage activation syndrome
  • Leukocytosis
  • Tachycardia
  • Arrhythmia
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Abdominal pain
  • Chills
  • Ataxia
  • Hypersensitivity
  • Bacterial, fungal and viral infections
  • Decreased immunoglobulins
  • Weight increased
  • Back pain, pain in extremity, bone pain
  • Headache
  • Tremor
  • Somnolence
  • Dizziness
  • Paraesthesia
  • Insomnia
  • Aphasia
  • Cough
  • Dyspnoea
  • Respiratory failure
  • Rash
  • Hypertension
  • Flushing
  • Potentially Fatal: Bone marrow suppression (e.g. neutropenia and febrile neutropenia); cytokine release syndrome; serious infections (e.g. sepsis, pneumonia, bacteraemia, opportunistic and catheter site infections); neurological toxicities (e.g. encephalopathy, convulsions); pancreatitis; tumour lysis syndrome.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing. 

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

  • Stroke
  • Epilepsy
  • Paresis
  • Aphasia
  • Severe brain injuries
  • Parkinson’s disease
  • Cerebellar disease
  • Organic brain syndrome
  • Dementia
  • Psychosis
  • History of neurologic signs and symptoms (e.g. dizziness, hypoaesthesia, hyporeflexia, dysaesthesia, memory impairment)
  • Prior treatment with cranial irradiation and anti-leukaemic chemotherapy (e.g. systemic high dose methotrexate or intrathecal cytarabine)
  • Renal and hepatic impairment
  • Children and elderly
  • Pregnancy
  •  Concomitant use with live viral vaccines

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Blinatumomab may interact with the following medicines:

  • May enhance adverse effect of live viral vaccines
  • May alter the serum concentration or increase risk of toxic effect of CYP450 substrates with narrow therapeutic index (e.g. warfarin, ciclosporin)

This article does not contain all possible drug interactions because it may change how your medications work or increase your risk for serious side effects.  Keep a list of all the products you use and consult it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins. 

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details. 

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking. 

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Symptoms of overdose may include the following:

  • Headache
  • Fever
  • Tremors

Seek medical help immediately. 

Available Brands:

  • Blincyto

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