Benserazide + Levodopa is a combination drug that is used in the treatment of Parkinson’s disease.  Levodopa gives rise to a substance called dopamine in the body. Most of the drug is converted to dopamine by an enzyme called dopa-decarboxylase. Benserazide is a drug that inhibits the enzyme decarboxylase to decrease levodopa conversion. This combination gives rise to fewer side effects such as nausea and vomiting.

Benserazide + Levodopa is used in the treatment of Parkinson’s disease

Benserazide + Levodopa is best taken on an empty stomach or before or an hour after meals. This medicine should not be used by people who have withdrawn from treatment of non-selective monoamine oxidase (MAO) inhibitors within 2 weeks.

This medicine should also be avoided by people with the following conditions:

  • Psychiatric disorders
  • Hormonal and endocrine problems
  • Kidney disease
  • Liver disease
  • Heart problems
  • Narrow-angle glaucoma
  • Malignant melanoma

This medicine should not be used in people less than 25 years old and those who are pregnant.

Benserazide + Levodopa may have the following side effects:

  • Gastrointestinal problems
  • Nausea
  • Vomiting
  • Anorexia
  • Diarrhoea
  • Taste disturbances
  • Peptic ulcer
  • Orthostatic hypotension
  • Abnormalities in heart rate and rhythm
  • Psychiatric disturbances e.g. mild elation, anxiety, agitation, insomnia, drowsiness, depression, aggression, hallucination
  • Somnolence
  • Sudden onset of sleep episodes
  • Abnormal involuntary movements e.g. dyskinesia, dystonia, chorea
  • Haemolytic anemia
  • Transient leucopenia and thrombocytopenia
  • Transient elevations of liver enzymes
  • Increased BUN and uric acid


Take special precautions in people with the following conditions:

  • Heart problems
  • Kidney disease
  • Liver problems
  • Lung disease
  • Hormonal and endocrine problems
  • Seizure disorders
  • Psychiatric disturbances such as depression
  • Open-angle glaucoma
  • Osteomalacia
  • History of peptic ulcer

This medicine should not be used among pregnant or breastfeeding women. When used, monitor for liver, psychiatric, blood, kidney and heart problems regularly.



Benserazide + Levodopa can interact with the following medicines:

  • TCAs
  • Phenothiazines
  • Butyrophenones
  • Thioxanthenes
  • Other antipsychotic agents
  • Reserpine
  • Papaverine
  • Phenytoin
  • Isoniazid
  • Ferrous sulfate
  • Pyridoxine
  • Anticholinergics
  • Methyldopa
  • Metoclopramide
  • Nonselective MAOIs
  • Cyclopropane
  • Halothane

Overdose signs and symptoms include the following:

  • Nausea
  • Vomiting
  • Insomnia
  • Confusion
  • Cardiac arrhythmia
  • Abnormal involuntary movements

If you think you have overdosed, seek medical help immediately.


Available Brand/s:

Madopar 250/Madopar HBS

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