BAGOXED

Do not use Bagoxed in people with the following conditions:

• Hypersensitivity
• Severe renal impairment: Pemetrexed is primarily excreted through the kidneys, so its use is contraindicated in patients with severe renal impairment (creatinine clearance less than 45 mL/min). It’s crucial to assess kidney function before initiating treatment with pemetrexed.
• Pregnancy and breastfeeding: Pemetrexed can cause harm to a developing fetus, so it is contraindicated during pregnancy. It is also not recommended for use while breastfeeding, as it may pass into breast milk and harm the nursing infant. If you are pregnant, planning to become pregnant, or breastfeeding, it’s important to discuss alternative treatment options with your healthcare provider.
• Concomitant yellow fever vaccine: Pemetrexed should not be administered within 4 weeks before or after receiving a live yellow fever vaccine. The vaccine can interfere with the body’s immune response and potentially reduce its effectiveness.

These are some of the common contraindications for pemetrexed, but it’s crucial to note that this is not an exhaustive list. Always consult with your healthcare provider to discuss your medical history, current medications, and any other relevant factors to determine if pemetrexed is suitable for you.

Your healthcare provider will consider your specific situation and weigh the potential benefits against the risks before prescribing pemetrexed or any other medication.

Bagoxed may have the following side effects:

• Nausea and vomiting: These are common side effects of pemetrexed treatment. Your healthcare provider may prescribe anti-nausea medications to help manage these symptoms.
• Fatigue: Many individuals may experience fatigue or tiredness while taking pemetrexed. It is important to get plenty of rest and conserve energy during treatment.
• Decreased appetite: Pemetrexed can cause a loss of appetite, which may result in weight loss. It is important to maintain proper nutrition during treatment, so discuss any appetite changes with your healthcare provider.
• Diarrhea or constipation: Pemetrexed can affect the digestive system, leading to diarrhea or constipation. Staying hydrated and following dietary recommendations from your healthcare provider can help manage these side effects.
• Low blood cell counts: Pemetrexed can temporarily lower the levels of red blood cells, white blood cells, and platelets in the bloodstream. This can lead to anemia, increased risk of infection, or bleeding. Regular blood tests will be conducted to monitor these levels.
• Skin rash or sensitivity: Some individuals may develop a skin rash or experience increased sensitivity to sunlight while taking pemetrexed. It’s important to protect your skin from the sun and notify your healthcare provider if you experience any skin changes.
• Hair loss: Pemetrexed can cause temporary hair loss. Hair usually grows back once treatment is completed, but it’s important to discuss any concerns with your healthcare provider.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

• Kidney function: Pemetrexed is primarily eliminated through the kidneys, so it’s important to assess kidney function before initiating treatment. Your healthcare provider may perform blood tests to evaluate your kidney function and adjust the dose accordingly
• Blood cell counts: Pemetrexed can temporarily reduce the levels of red blood cells, white blood cells, and platelets in the bloodstream. Regular blood tests will be conducted to monitor these levels. If your blood cell counts are too low, your healthcare provider may adjust the dose or temporarily stop treatment
• Liver function: Pemetrexed is metabolized in the liver, so it’s important to assess liver function before starting treatment. Your healthcare provider may perform blood tests to evaluate your liver function and adjust the dose accordingly.
• Pregnancy and breastfeeding: Pemetrexed can cause harm to a developing fetus, so it’s important to use effective contraception during treatment. It is also not recommended to breastfeed while taking pemetrexed, as it may pass into breast milk and harm the nursing infant. Consult with your healthcare provider for advice on contraception methods and breastfeeding considerations.
• Sun exposure: Pemetrexed may cause increased sensitivity to sunlight. It’s important to protect your skin from excessive sun exposure by wearing protective clothing and using sunscreen with a high sun protection factor (SPF).

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Bagoxed may interact with the following medicines:

• Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs, such as ibuprofen and naproxen, can increase the risk of kidney problems when taken with pemetrexed. It’s generally recommended to avoid or minimize the use of NSAIDs during treatment with pemetrexed.
• Proton pump inhibitors (PPIs): PPIs, used to reduce stomach acid, can reduce the effectiveness of pemetrexed. Your healthcare provider may recommend alternative medications to manage acid-related issues if you are taking pemetrexed.
• Vaccinations: Pemetrexed may weaken the immune system, so live vaccines should be avoided during treatment. Consult with your healthcare provider regarding vaccinations and discuss the appropriate timing
• Diuretics: Diuretics can affect kidney function, and when taken with pemetrexed, they may increase the risk of kidney problems. Your healthcare provider will monitor your kidney function and adjust the medication regimen if needed.
• Warfarin: Pemetrexed may interact with warfarin, an anticoagulant medication used to prevent blood clots. Your healthcare provider may adjust the dose of warfarin or closely monitor your blood clotting levels when using pemetrexed.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you suspect an overdose, contact your doctor right away.

Available Brands:

• Bagoxed