Take extra caution in patients with the following medical conditions:
- Patient taking other drugs known to prolong QT interval (e.g. class IA or III antiarrhythmics, antipsychotic agents, antidepressants, fluoroquinolones).
- Patient with coronary artery disease,
- Electrolyte disturbances (e.g. hypomagnesaemia),
- Severe cardiac insufficiency, clinically relevant bradycardia or conduction disturbances;
- Pregnancy and lactation.
- Hepatic and moderate to severe renal impairment.
- Patients with renal impairment concurrently take atazanavir or ritonavir-containing regimens.
- Myasthenia gravis.
Before taking this medicine, tell your physician or pharmacist if you are allergic to it or if you have some other hypersensitivities. This drug may contain inert ingredients, which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.
Baclecin-500 may interact with the following medicines:
- May increase the risk of torsades de pointes with quinidine or disopyramide.
- Increased risk of bleeding and elevated INR and prothrombin time with warfarin.
- May elevate the serum concentrations of digoxin and CYP450 substrates (e.g. alprazolam, carbamazepine, cilostazol, ciclosporin, methylprednisolone, omeprazole, quetiapine, sildenafil, sirolimus, tacrolimus, vinblastine, theophylline, valproate, tolterodine).
- May induce metabolism and decrease efficacy with CYP3A inducers (e.g. rifampicin, phenytoin, carbamazepine, phenobarbital).
- Increased or prolongation of sedation with triazolam.
- May reduce the plasma levels with strong CYP450 inducers (e.g. efavirenz, nevirapine, rifabutin, rifapentine).
- May decrease the plasma concentrations of zidovudine. Ritonavir significantly inhibits the metabolism of clarithromycin. Concomitant use with atazanavir, itraconazole, saquinavir, or certain Ca channel blockers (e.g. verapamil, amlodipine, diltiazem) may result in bi-directional drug interactions.
- Decreased exposure with etravirine.
- May result in significant hypoglycaemia with oral hypoglycaemics (e.g. sulfonylureas, repaglinide, nateglinide) and insulin.
- Increased plasma concentration and exposure with fluconazole.
Inform your physician about the drugs you take, including over-the-counter medications, prescribed drugs, supplements and vitamins.
This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.
The effects of certain medications can change if you simultaneously consume different medications or herbal products. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.
While utilizing this drug, don’t start, stop, or change the dose of other medicines you use without your physician’s advice.