AXITINIB

Axitinib is a second generation targeted drug and also a potent tyrosine kinase inhibitor. It prevents angiogenesis, tumour growth, and cancer progression by acting as an inhibitor to the vascular endothelial growth factor receptors (VEGFR) tyrosine kinase 1, 2, and 3.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Uses

Axitinib is used in the following conditions:

Advanced renal cell carcinoma

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Axitinib in people with the following conditions:

Recent active GI bleeding
Untreated brain metastases
Severe hepatic impairment (Child-Pugh Class C)
Lactation

Side Effects

Axitinib may have the following side effects:

Hypertension
Posterior reversible leukoencephalopathy syndrome
Proteinuria
Thyroid dysfunction
Increased hemoglobin or hematocrit
Impaired wound healing
Headache
Fatigue
Asthenia
Gastrointestinal disturbances
Decreased appetite
Nausea
Vomiting
Oral mucositis
Taste disturbance
Vocal changes
Dysphonia
Abdominal pain
Dyspepsia
Diarrhoea
Constipation
Increased hepatic enzymes and bilirubin
Weight loss
Arthralgia
Myalgia
Palmar-plantar erythrodysaesthesia
Rash
Dry skin
Itch
Erythema
Alopecia
Electrolyte disturbance
Cardiac failure
Arterial thrombotic events (e.g. MI, TIA, CVA, retinal artery exclusion)
Venous thrombotic events (e.g. DVT, pulmonary embolism, retinal vein occlusion or thrombosis)
Hypertensive crisis
Hemorrhagic events (e.g. GI or cerebral haemorrhage, haemoptysis, haematuria, melaena)
Gastrointestinal perforation
Fistula formation

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

Hypertension
Cardiac disease
History of or risk for thrombosis
Patients taking strong CYP3A4 inhibitors
Withhold treatment at least 24 hr prior to scheduled surgery
Moderate hepatic impairment (Child-Pugh Class B)
Pregnancy

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Axitinib may interact with the following medicines:

Ketoconazole
Ritonavir
Clarithromycin
Rifampicin
Phenytoin
Carbamazepine
Bisphosphonate derivatives

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

Symptoms of overdose may include the following:

Dizziness
Hypertension
Seizures
Haemoptysis

Seek medical help immediately.

Available Brands:

Inlyta