Aspirin is a salicylate that treats pain and reduces fever or inflammation. Caffeine is a stimulant and works by relaxing the muscle contractions in blood vessels to improve blood flow.

This combination medication is used to treat pain including, headache, muscle aches, sprains, tooth extraction and toothache, menstrual cramps, arthritis and rheumatism, and pain and fever of the common cold. This medication may also be used in other conditions to be determined by your doctor.

Do not take this drug:

  • For pain more than 10 days (adults) or 5 days (children) unless directed by a doctor.
  • For fever more than 3 days unless directed by your doctor.
  • More than prescribed. Over dosage may cause serious problems.

Common side effects may include:

  • Nausea
  • Vomiting
  • Stomach Upset
  • Heartburn
  • Trouble Sleeping
  • Increased Urination

Notify your doctor promptly if any of these symptoms persist or worsen.

Your doctor may have prescribed this medication because he or she judged that the benefit to you is greater than the risk of side effects.

Notify your doctor promptly if any of these symptoms persist or worsen.

Your doctor may have prescribed this medication because he or she judged that the benefit to you is greater than the risk of side effects.

Serious side effects may include:

  • Mental or Mood Changes (such as Nervousness, Agitation)
  • Shaking (Tremor)
  • Fast, Pounding or Irregular Heartbeat
  • Hearing Changes (such as Ringing in the Ears, Difficulty Hearing)
  • Easy Bleeding or Bruising
  • Unusual Tiredness
  • Signs of Kidney Problems (such as Change in the Amount of Urine)
  • Nausea
  • Vomiting
  • Yellowing Eyes or Skin
  • Dark Urine

Rare side effects may include:

  • Bleeding from the Stomach or Intestine
  • Black or Tarry Stools
  • Stomach or Abdominal Pain
  • Vomit that Looks Like Coffee Grounds
  • Trouble Speaking
  • Weakness on One Side of the Body
  • Sudden Vision Changes
  • Severe Headache

Seek immediate medical attention if you experience any of these serious side effects.


Before taking this drug, tell your doctor or pharmacist:

  • If you are allergic to any content of this drug or if you have other allergies.
  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • Your medical condition such as:
    • Asthma
    • Bleeding or Clotting Problems
    • Growths in the Nose (Nasal Polyps)
    • Kidney or Liver Problems
    • Stomach or Intestinal Problems (eg, Ulcer, Inflammation)
    • Heart Problems
    • Heartburn
    • Upset Stomach
    • Stomach Pain
    • Hives
    • Influenza (Flu)
    • Chickenpox
    • Vitamin K Deficiency
    • Anxiety
    • Trouble Sleeping
    • Heart Problems
  • If you are a child with certain conditions such as:
    • Stroke
    • Weakened Blood Vessel (Cerebral Aneurysm) or Bleeding in the Brain
    • Rheumatic Disease (eg, Rheumatoid Arthritis)
    • Kawasaki Syndrome (A Rare Inflammation Causing Heart Problems in Children)



Drug interactions may either lessen the effectiveness of this drug or heighten the risk for severe side effects. It’s important to inform your doctor all the medication including prescription and non-prescription and herbal medicines you are taking or going to take.

Possible interactions with this drug are:

  • Ibuprofen (Advil, Motrin)
  • Alcohol
  • Other Drugs that Contain Caffeine or Aspirin
  • Other Cold or Allergy Medicine, Diet Pills, or Pain Medication
  • Ketoprofen
  • Antidepressant such as Citalopram, Escitalopram, Fluoxetine (Prozac), Fluvoxamine, Paroxetine, Sertraline (Zoloft), Trazodone, or Vilazodone

Call emergency hotline if someone has overdosed and has serious symptoms such as passing out or trouble breathing.

Symptoms of overdose may include:

  • Agitation
  • Anxiety
  • Confusion
  • Fever
  • Hearing Loss
  • Lethargy
  • Lightheadedness, Especially Upon Standing
  • Muscle Twitching
  • Nausea
  • Rapid Breathing
  • Rapid or Irregular Heartbeat
  • Ringing in the Ears
  • Seizures
  • Shortness of Breath
  • Stomach Pain
  • Trouble Sleeping
  • Vomiting


Available brand/s:

  • Caffeine
  • Dipyridamole
  • Phenacetin

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