The specific mechanism of action of Armodafinil, an R-enantiomer of modafinil, remains uncertain. It appears to bind to the dopamine transporter and inhibit dopamine re-uptake in the brain, resulting in higher extracellular dopamine levels. It is not a dopamine receptor agonist, and it does not appear to bind or inhibit the majority of hormones, enzymes, or receptors thought to be involved in the sleep-wake cycle.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Armodafinil is used in the following conditions:

  • Narcolepsy
  • Obstructive sleep apnea
  • Shift-work sleep disorder

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Armodafinil in people with the following conditions:

  • Hypersensitivity
  • Pregnancy

Armodafinil may have the following side effects:

  • Agitation
  • Anxiety
  • Depression
  • Mania
  • Hallucinations
  • Irritability
  • Nervousness
  • Suicidal thoughts
  • Delusions
  • Aggression
  • Persistent sleepiness
  • Palpitations
  • Diarrhea
  • Dry mouth
  • Nausea
  • Vomiting
  • Thirst
  • Dyspepsia
  • Upper abdominal pain
  • Constipation
  • Fatigue
  • Pain
  • Fever
  • Flu-like symptoms
  • Seasonal allergy
  • Increased heart rate
  • Increased gamma-glutamyl transferase
  • Anorexia
  • Decreased appetite
  • Headache
  • Dizziness
  • Disturbance in attention
  • Migraine
  • Paresthesia
  • Tremor
  • Nervousness
  • Depressed mood
  • Insomnia
  • Polyuria
  • Dyspnea
  • Rash
  • Contact dermatitis
  • Hyperhidrosis

Potentially Fatal: 

  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Drug rash with eosinophilia and systemic symptoms (DRESS)
  • Multi-organ hypersensitivity
  • Anaphylaxis
  • Angioedema

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • History of psychosis, mania or depression
  • History of drug abuse
  • History of angina or myocardial infarction
  • Tourette syndrome and other tic disorders
  • History of left ventricular hypertrophy
  • Mitral valve prolapse
  • Obstructive sleep apnea
  • Avoid abrupt withdrawal following chronic use
  • Hepatic impairment
  • Elderly
  • Lactation

Prior in taking this medicine, tell your physician or pharmacist if you have allergies or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Armodafinil may interact with the following medicines:

  • Carbamazepine
  • Oxcarbazepine
  • Phenytoin
  • Phenobarbital
  • Rifampicin
  • Rifabutin
  • Indinavir
  • Nelfinavir
  • Ritonavir
  • Saquinavir
  • Erythromycin
  • Clarithromycin
  • Chloramphenicol
  • Ketoconazole
  • Itraconazole
  • Nefazodone
  • Verapamil
  • Diltiazem
  • Ciclosporin
  • Steroidal contraceptives
  • Midazolam
  • Triazolam
  • Quetiapine
  • Diazepam
  • Phenytoin
  • Propranolol
  • Clomipramine
  • Omeprazole

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If an overdose is suspected, call your health care provider immediately.

Available brands:

  • Nuvigil

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