Description: Altretamine is an antineoplastic agent structurally similar to the alkylating agent tretamine but exact mode of action is unknown.

Altretamine is for the treatment of ovarian cancer after other treatments have not been successful.

How to use altretamine

Take by mouth, usually 4 times daily (after meals and at bedtime) or take only the dosage as prescribed by doctor. Do not overdose. Pregnant women should not handle this drug.

Serious blood disorders (decreased bone marrow function leading to low number of blood cells such as white cells, red cells, and platelets) or nerve/brain disorders, signs of an infection (e.g., fever, persistent sore throat), easy bruising/bleeding, unusual tiredness, fast/pounding heartbeat, numbness/tingling of the arms/legs, mental/mood changes, seizures, loss of coordination, dizziness.

Common side effects include: Nausea, vomiting, or loss of appetite, temporary hair loss.

Serious side effects occur: change in the amount of urine, yellowing eyes/skin, dark urine, severe stomach/abdominal pain.

Contact your doctor if you experience allergic reactions or symptoms mentioned above.


Inform your doctor or pharmacist your allergies, medical history, especially of:  kidney disease, liver disease, brain/nerve disorders, blood/bone marrow disorders (e.g., low levels of platelets/white blood cells/red blood cells).

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.

Pregnant and breastfeeding women should take caution, consult your doctor before taking and handling this drug.



Serious interactions may occur: nalidixic acid, pyridoxine (vitamin B6), MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine).


Get emergency medical help when overdose is suspected.

Missed Dose: Follow the schedule of you dose for best treatment outcome.

Storage: Store medication in room temperature.  Do not expose to light and moisture. Do not store in the bathroom. Keep all medications away from pets and children.  Do not flush medications down the toilet or pour into a drain.

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