ALENDRONIC ACID + CHOLECALCIFEROL - Watsons Health

ALENDRONIC ACID + CHOLECALCIFEROL

Alendronic acid is a drug that belongs to a class of medicines known as bisphosphonates. It acts by inhibiting bone resorption which is mediated by osteoclasts, further leading to increase in bone mineral density.

Cholecalciferol is a substance that is produced by the skin that results from the conversion of 7-dehydrocholesterol to split (seco) sterol previt D3 and subsequently colecalciferol (vit D3) through ultraviolet light. Vitamin D3 is the natural precursor of1,25-dihydroxyvitamin D3 or calcitriol, which in turn mobilizes calcium in the bones. Calcitriol increases the intestinal absorption of calcium and phosphate and also acts to regulate bone formation and bone resorption.

Alendronic Acid + Cholecalciferol is use in the treatment of postmenopausal osteoporosis. It is also used to increase bone mass in men with osteoporosis.

Alendronic Acid + Cholecalciferol should not be given to those with hypersensitivity to bisphosphonates and vitamin D derivatives. It should also not be given to people with low blood calcium levels (hypocalcaemia), as well as those with abnormalities in the oesophagus as well as those with an inability to stand or sit upright for at least 30 minutes.

Alendronic Acid + Cholecalciferol can bring about the following side effects:

  • Abdominal pain
  • Dyspepsia
  • Oesophageal ulcer
  • Dysphagia
  • Abdominal distension
  • Acid regurgitation
  • Diaphyseal and subtrochanteric femur fracture
  • Severe muscle, bone and joint pain
  • Upper gastrointestinal mucosa irritation
  • Osteonecrosis of the jaw
  • Oesophageal cancer
  • Headache
  • Dizziness
  • Vertigo
  • Alopecia
  • Pruritus
  • Asthenia
  • Peripheral oedema

Precautions

Take extra caution in patients with the following conditions:

  • Underlying upper gastrointestinal disease
  • Vitamin D deficiency
  • Hypocalcaemia
  • Diseases associated with unregulated production of calcitriol (e.g. leukaemia, lymphoma, sarcoidosis)
  • Liver and kidney impairment
  • Pregnancy and lactation

 

Interactions

Alendronic Acid + Cholecalciferol may interact with the following medicines:

  • NSAIDs
  • Antacids
  • Calcium salts
  • Mineral oil
  • Orlistat
  • Cholestyramine
  • Colestipol
  • Anticonvulsants
  • Cimetidine
  • Thiazide diuretics

Signs and symptoms of alendronate overdose include the following:

  • Heartburn
  • Gastritis
  • Ulcer
  • Upset
  • Stomach
  • Esophagitis
  • Hypocalcaemia
  • Hypophosphataemia

If you think you may have overdosed, seek medical help immediately.

 

Available Brands:

  • Fosavance
  • Fosdin

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