Advanced molecular detection (AMD) combines cutting-edge next-generation genomic sequencing technology with analytics and epidemiological knowledge from throughout the country to help medical experts locate, monitor, and eliminate disease-causing pathogens quicker than ever before.
Furthermore, laboratory approaches for sequencing and extracting pathogen DNA, such as whole genome sequencing (WGS) and next-generation genomic sequencing, are part of advanced molecular detection (AMD). Portable sequencers for field testing are available, as are tabletop and full-sized sequencers for laboratory applications.
What are the types of sequencing?
- Whole Genome Sequencing
This is a laboratory process that establishes the order of all or most of the nucleotides in the genome of pathogenic germs to understand how pathogens migrate across populations.
- Next-Generation Genomic Sequencing
Next-generation sequencing refers to sequencing technology capable of simultaneously processing enormous amounts of genomic material.
How does AMD work?
Obtaining correct findings on diseases and conditions requires thorough tests and processes. Here’s how advanced molecular detection (AMD) works:
- Sample collection: The procedure starts with gathering biological samples from the environment or persons.
- Nucleic acid extraction: The nucleic acids (RNA or DNA) are extracted after collecting the samples.
- Molecular amplification: This occurs following the intended genetic material has been extracted using procedures like polymerase chain reaction (PCR) or other amplification methods.
- Pathogen identification: This involves analyzing the amplified genetic material to determine the presence of certain infections.
- Genomic analysis: Pathogen identification is accompanied by genomic analysis to better understand the variability and genetic traits of the pathogens.
- Bioinformatics analysis: The massive quantity of genetic data produced by AMD necessitates advanced bioinformatics analysis.
- Data integration and interpretation: The findings of genomic and molecular studies are integrated and analyzed in the context of public and epidemiological health data.
- Reporting and response: AMD insights and results are shared with public health authorities, academics, and relevant participants or stakeholders to influence decision-making and steer public health measures.
Is this helpful in the medical field?
Even though infectious diseases are tiny, sequencing their DNA yields massive genomic data. Advanced molecular detection (AMD) specialists employ high-performance computer equipment to create programs known as pipelines to examine the data. Once established and confirmed, these processes help accelerate pathogen characterization and detection.
Moreover, scientists may quickly determine which strain of pathogens or species is implicated in an epidemic and certain traits that might be significant for battling it, such as antibiotic resistance, by putting DNA sequence data into a specialized pipeline.