Description: Adefovir dipivoxil inhibits viral replication which can be used in patients with lamivudine-resistant hepatitis B..

This medication is used to treat a chronic viral infection of the liver (hepatitis B) in people 12 years of age and older. It works by slowing the growth of the virus. It is not a cure for hepatitis B and does not prevent the passing of hepatitis B to others.

How to use adefovir

Take this medication by mouth, with or without food. Take as prescribed and dosed.

An HIV test is recommended both before and during treatment to ensure appropriate prescription

Report to your physician any worsening of your condition, decreased response to therapy.

Discontinuation of Adefovir has resulted to severe worsening of hepatitis (rarely including death). Symptoms that manifest organ damage such as unusual weakness or fatigue, dark urine, yellowing of the skin or eyes, abdominal or stomach pain, drowsiness, muscle aches or weakness, trouble breathing (e.g., rapid breathing or very shallow breathing), or fast or irregular heartbeat.

Adefovir may cause kidney damage in patients with kidney disease.

If you have an HIV infection that is not being treated, adefovir can cause your HIV infection to be drug-resistant.

Adefovir may cause the following side effects:

  • weakness
  • headache
  • fever
  • increased cough
  • nausea
  • vomiting
  • diarrhea
  • gas

If you experience these symptoms and In case of allergic reactions, consult your doctor immediately.


Inform your doctor or pharmacist your allergies, medical history, especially especially of: HIV infection, kidney problems, liver transplant, being very overweight (obese).

For pregnant and breastfeeding mothers, consult your doctor before use.



Products that may interact with this drug include: aminoglycosides (such as gentamicin, amikacin), amphotericin B, cyclosporine, non-steroidal anti-inflammatory drugs (such as ibuprofen), tacrolimus, vancomycin.  Do not take products that contain tenofovir with this medication.


Get emergency medical help when overdose is suspected.

Missed Dose: As soon as you remember, take a regular dose or if the time of the next dose is near, wait for it before taking another dose and resume your usual schedule. Do not increase the dose to compensate for the missed dose.

Storage: Store medications in Room temperature Do not expose to light and moisture Do not store in the bathroom Keep all medications away from pets and children Do not flush medications down the toilet or pour into a drain.



Also marketed as

  • Hepsera [ GlaxoSmithKline ]

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