Acantholysis bullosa is a rare condition that causes pustules, fragile, and blisters in the skin. These skin blisters might come out in reaction to minor wounds, heat, scratching, rubbing, or adhesive bandage. In serious instances, the blisters might transpire inside the body, including the mouth lining or stomach. 

Most types of these conditions are acquired through genetics. Moreover, the disease often emerges in early childhood or infancy. Some individuals don’t have any indication until they are in the early adulthood stage. 

Up until now, acantholysis bullosa has no remedy, even though mild cases may get better with age. The treatment mostly focuses on taking care of the blisters and stopping the development of new ones.


There are five types of acantholysis bullosa, and these vary, depending on where your blisters come out. 

  • Epidermolysis Bullosa Simplex
  • Junctional Epidermolysis Bullosa
  • Dystrophic Epidermolysis Bullosa
  • Kindler Syndrome
  • Epidermolysis Bullosa Acquisita


The symptoms of acantholysis bullosa depend on what type it is. These symptoms include:

  • Blisters inside the mouth or throat
  • Fragile skin
  • Nails that don’t form or thicken
  • Hair loss, scalp blistering, and scarring
  • Thicker skin on the soles of the feet and palms
  • Pimples or small white skin bumps
  • Atrophic scarring
  • Painful, itchy skin
  • Dysphagia or difficulty swallowing
  • Dental issues

Normally, the symptoms of epidermolysis bullosa first emerge in toddlers or babies when they start to walk or perform physical activities that prompt the condition.


To diagnose acantholysis bullosa, the doctor may ask you about your symptoms, physical activities and perform a physical exam to see the affected area. Afterward, the doctor might get a skin sample and send it to the laboratory to examine. 

Once the doctor confirms you have acantholysis bullosa, he/she may give you medication or treatment that helps manage the symptoms. 


Currently, there’s still no cure for acantholysis bullosa. Nevertheless, there are available treatments to help manage the conditions. 

For serious cases, the doctor may recommend treatment similar to burns. You’ll be required to know how to treat your wound properly and how to secure the affected areas. The doctor can also give you prescription medicine to help ease the pain. 

In some instances, surgery might be needed. Thus, it’s crucial to seek immediate medical attention so that the doctor can treat it immediately to prevent any severe complications.

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