Tizanidine is a TCA that is used as a muscle relaxant. It is a centrally acting α₂ adrenergic agonist. It reduces spasticity by increasing presynaptic inhibition of motor neurons and has no direct effect on skeletal muscle, the neuromuscular junction or on monosynaptic spinal reflexes.
This drug is used in treating muscle spasms caused by some conditions (like multiple sclerosis, spinal cord injury). It works by helping to relax the muscles.
Do not use in patients with severe hepatic dysfunction.
Tizanidine can give rise to side effects such as:
Precautions
Use with precaution in the following conditions:
Monitor liver function tests regularly. Stop its treatment if the liver enzymes are raised persistently >3 times the upper limit of normal range. Avoid abrupt withdrawal of therapy.
Interactions
Tizanidine may interact with the following medications:
Symptoms of overdose may include:
Available Brand:
Sirdalud
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