PRETHCAMIDE

Indications: Respiratory stimulant.
Dosage: Adult : PO 100 mg 3 times/day.
Dosage Details: Oral
Respiratory stimulantAdult: 100 mg tid.
Contraindications: Epilepsy or other convulsive disorders, cerebral oedema, cerebrovascular accident, head injury, acute severe asthma, physical obstruction of the airway, severe hypertension, ischaemic heart disease, hyperthyroidism, pheochromocytoma.
Special Precautions: mild-moderate hypertension, impaired cardiac reserve; liver or renal dysfunction.
Adverse Drug Reactions: Dyspnoea, resp problems; muscular, GI, CNS and CV effects.

 

Drug Interactions: Concurrent use with anaesthetics may cause cardiac arrhythmias. Increased pressor effects when used with sympathomimetics or MAOIs. May mask the residual effects of neuromuscular blockers.

 

Mechanism of Action: Description: Prethcamide is a central and resp stimulant with a brief duration of action. It acts by stimulation of peripheral chemoreceptors and central resp centers. It has pressor effects and may also increase catecholamine release.
Therapeutic Category: Respiratory Stimulants

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