DACLATASVIR

Daclatasvir is an orally available Hepatitis C non-structural protein 5A (NS5A) inhibitor which breaks the viral RNA replication complex, suspends the viral HCV RNA production and blocks viral replication.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Uses

Daclatasvir is used in the following conditions:

Chronic Hepatitis C

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Daclatasvir in people with the following conditions:

Hypersensitivity
Pregnancy (especially in combination with ribavirin and peginterferon alfa)
Lactation

Side Effects

Daclatasvir may have the following side effects:

Anaemia
Neutropenia
Thrombocytopenia
Leucopenia
Lymphopenia
Ear and labyrinth disorders
Vertigo
Tinnitus
Dry eye
Blurred vision
Reduced visual acuity
Nausea
Diarrhoea
Vomiting
Abdominal pain
Constipation
Dry mouth
Flatulence
GERD.
Irritability
Fatigue
Asthenia
Influenza-like illness
Pyrexia
Weight decreased
Increased ALT, AST and blood bilirubin
Decreased appetite
Myalgia
Arthralgia
Headache
Dizziness
Migraine
Disturbance in attention
Insomnia
Depression
Anxiety
Sleep disorder
Libido decreased
Mood swings
Nasopharyngitis
Dyspnoea
Nasal congestion
Cough
Rash
Pruritus
Alopecia
Dry skin
Hot flush
Hypertension
Potentially Fatal: Hepatitis B virus reactivation resulting in fulminant hepatitis and hepatic failure.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Precautions

Take extra caution in patients with the following medical conditions:

Patients with underlying cardiac comorbidities
Diabetes mellitus
Advanced hepatic disease
Hepatitis B co-infection
Not intended for use as a monotherapy
Patients taking moderate CYP3A4 inducers or strong CYP3A4 inhibitors
Hepatic impairment

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Daclatasvir may interact with the following medicines:

CYP3A4 inducers
Asunaprevir-containing regimen
P-gp substrates (e.g. dabigatran, digoxin)\
Organic anion transporting polypeptide (OATP) 1B1 or 1B3
HMG-CoA reductase inhibitors
Antidiabetic agents
Vitamin K antagonists (e.g. warfarin)
Potentially Fatal: Concomitant use with sofosbuvir and amiodarone, strong CYP3A4 or P-gp inducers (e.g. phenytoin, carbamazepine, oxcarbazepine, phenobarbital, rifampicin, rifabutin, rifapentine, systemic dexamethasone).

This article does not contain all possible drug interactions because it may change how your medications work or increase your risk for serious side effects. Keep a list of all the products you use and consult it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

Daclatasvir has no known symptoms of overdose. If taken in excess, seek medical help immediately.

Available Brands:

Mydekla