CABOZANTINIB

Cabozantinib is an antineoplastic drug, specifically a receptor tyrokinases (RTKs) inhibitor. It promotes the death of cancer cells, inhibiting the growth of tumours, preventing the spread of cancer cells, and angiogenesis.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Uses

Cabozantinib is used in the following conditions:

Unresectable locally advanced or metastatic medullary thyroid carcinoma
Advanced renal cell carcinoma; Hepatocellular carcinoma
Metastatic medullary thyroid carcinoma, Unresectable locally advanced medullary thyroid carcinoma
Advanced renal cell carcinoma, Hepatocellular carcinoma

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Cabozantinib in people with the following conditions:

History of haemorrhage or haemoptysis
Lactation

Side Effects

Cabozantinib may have the following side effects:

Hypertension
Reversible posterior leukoencephalopathy syndrome (RPLS)
Palmar-plantar erythrodysesthesia syndrome
Diarrhoea
Proteinuria
Osteonecrosis of the jaw
Nephrotic syndrome
Wound healing impairment
Anaemia
Thrombocytopenia
Neutropenia
Tinnitus
Hypothyroidism
Nausea
Vomiting
Stomatitis
Constipation
Abdominal pain
Dyspepsia
GERD
Haemorrhoids
Oral pain
Dry mouth
Fatigue
Asthenia
Peripheral oedema.
Hepatic encephalopathy
Absces
Decreased WBC count
Decreased appetite
Hypomagnesaemia
Hypokalaemia
Dehydration
Hyperglycaemia
Hypoglycaemia
Hypophosphatemia
Hypoalbuminemia
Hyponatraemia
Hyperkalaemia
Hypocalcaemia
Hyperbilirubinemia
Limb pain
Muscle spasms
Arthralgia
Dysgeusia
Headache
Dizziness
Peripheral sensory neuropathy.
Dysphonia
Dyspnea
Cough
Pulmonary embolism
Rash
Alopecia
Dry skin
Dermatitis acneiform
Hair discolouration
Erythema

Potentially Fatal:

Serious haemorrhage (e.g. haemoptysis, gastrointestinal bleeding), gastrointestinal perforations, and fistula, thromboembolic events (e.g. pulmonary embolism, arterial thromboembolism).

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

Patient with hypertension
Wound healing complications
Renal and hepatic impairment
Pregnancy.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Cabozantinib may interact with the following medicines:

Ketoconazole
itraconazole
Rifampin
Rifabutin
Rifapentine
Phenobarbital
Phenytoin
carbamazepine

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

If an overdose is suspected call your healthcare provider immediately.

Available Brands:

Cabometyx
Cometriq