Chlormethine

Chlormethine is an alkylating agent and a prototype anticancer chemotherapeutic drug which prevents the DNA replication and RNA transcription through the formation of carbonium ions. This leads to cross-linking of DNA strands and causes miscoding, breakage and replication failure, thus inhibiting cell division and DNA synthesis leading to cell death.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Uses

Chlormethine is used in the following conditions:

Malignant effusions
Advanced Hodgkin’s disease

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Chlormethine in people with the following conditions:

Hypersensitivity
Pregnancy
Lactation
Severe myelosuppression or infection

Side Effects

Chlormethine may have the following side effects:

GI disturbances
Anorexia
Metallic taste
Myelosuppression
Tinnitus
Vertigo
Deafness
Headache
Drowsiness
Fever
Neurological symptoms
Jaundice
Maculopapular rashes
Severe irritation due to extravasation
Impaired spermatogenesis
Temporary or permanent inhibition of fertility
Strong vesicant action
Menstrual disturbances
Azoospermia
Precipitation of herpes zoster
Alopecia
Hyperuricemia

Potentially fatal:

Hypersensitivity
Thrombophlebitis
Bone depression
Severe and fatal depression with anemia
Lymphocytopenia
Granulocytopenia
Thrombocytopenia with consequent hemorrhage

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

Concurrent radiotherapy: secondary leukemia
Monitor hepatic, renal and bone marrow function
Avoid contact with skin and mucous membranes due to strong vesicant action.

Prior in taking this medicine, tell your physician or pharmacist if you have allergies or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Chlormethine may interact with the following medicines:

Impaired response to vaccines
Alcohol

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

If overdose is suspected call your health care provider immediately.

Available Brands:

Mustargen