Estradiol + Norethisterone is an sex hormone that is synthetically prepared and is like endogenous estrogen. In menopause, estradiol substitutes for estrogen production and decreases its side effects. Estradiol likewise avoids bone loss following menopause or ovariectomy. Norethisterone lessens the estradiol-instigated risk of endometrial hyperplasia in women who have not undergone hysterectomy.