OBINUTUZUMAB

Obinutuzumab is an anti-cancer drug that is also known as Type II anti-CD20 and recombinant humanized monoclonal antibody. After binding to CD20, this drug causes lysis of B lymphocytes by inducing direct cell death and by leading to antibody-dependent mobile cytotoxicity (ADCC) and antibody-dependent cell phagocytosis (ADCP). It additionally mediates complement dependent cytotoxicity.

Uses

It is used in the treatment of cancers, such as chronic lymphocytic leukemia, follicular lymphoma and marginal zone lymphoma.

Warnings

Obinutuzumab should not be given to people with the following conditions:

Hypersensitivity to this drug including serum sickness
Those who just had live viral vaccines

Side Effects

Obinutuzumab may have some side effects such as the following:

Alopecia
Anemia
Anxiety
Arthralgia
Asthenia
Atrial fibrillation
Cardiac failure
Chest pain
Constipation
Cough
Depression
Diarrhea
Dyspepsia
Eczema
Extremities, back and bone pain
Fatigue
HBV reactivation leading to fulminant hepatitis and hepatic failure
Headache
Herpes zoster and herpes simplex virus infection
Hyper- or hypo-kalemia
Hypersensitivity reactions including serum sickness
Hypertension
Hyperuricemia
Hypoalbuminemia
Hypocalcemia
Hyponatremia
Hypophosphatemia
Hypotension
Increased AST or ALT
Increased serum creatinine
Influenza
Infusion related reactions
Insomnia
Leukopenia
Lung infection, pneumonia
Lymph node pain
Lymphopenia
Nasal congestion
Nasopharyngitis
Nausea
Neutropenia, thrombocytopenia, hemorrhage
Oropharyngeal pain
Pharyngitis
PML (rare)
Pruritus
Pyrexia
Rhinitis
Rhinorrhea
Sepsis
Serious bacterial, fungal and viral infections
Sinusitis
Tumor lysis syndrome
Upper respiratory tract infection
UTI

Precautions

Precautions

Special precautions should be observed in people with the following conditions:

Patients with history or current serious infection especially hepatitis B virus (HBV) infection
Risk of tumor lysis syndrome (example high tumor burden, high lymphocyte count)
Cardiac and respiratory impairment
Kidney impairment
Pregnancy
Lactation

Interactions

Obinutuzumab may interact with the following medicines:

Antihypertensive agents
Anticoagulants, platelet inhibitors
Live vaccines

Overdose & Brands

If you think you may have used Obinutuzumab more than the usual dose, seek medical help immediately.

Available Brands:

Gazyva