UNCONJUGATED BENIGN BILIRUBINEMIA

Unconjugated Benign Bilirubinemia is a rare hereditary liver condition in which the body is unable to effectively handle bilirubin, a yellowish waste product produced by the breakdown of old or worn-out red blood cells (hemolysis). Because they have a decreased amount of a particular liver enzyme necessary for bilirubin removal, people with Gilbert syndrome have high levels of bilirubin (hyperbilirubinemia).

The majority of those who are afflicted show no symptoms (asymptomatic) or very minor yellowing of the skin, mucous membranes, and eye whites (jaundice). It’s possible that jaundice won’t show up until puberty. Stress, effort, dehydration, alcohol use, fasting, and/or illness can all cause a rise in bilirubin levels.

When one of these illnesses is present, jaundice may occur in certain people. Gilbert syndrome is an autosomal recessive disease that is handed down through the generations.

SYMPTOMS

Symptoms for unconjugated benign bilirubinemia may include:

Mild jaundice

This can occur in young people and is more prevalent in men than in women. Jaundice episodes are frequently missed.

Unconjugated Benign Bilirubinemia

This is characterized by variables of the blood bilirubin (hyperbilirubinemia). Stress, pressure, dehydration, fasting, illness, or cold exposure can all cause a rise in bilirubin levels. Many people only get jaundice after one of these causes raises their bilirubin levels.

DIAGNOSIS

Unconjugated benign bilirubinemia is frequently diagnosed when blood collected for a normal health check or another disease, such as an infection, reveals moderately increased bilirubin levels.

Furthermore, because bilirubin levels fluctuate, blood testing may not always reveal high bilirubin. In addition, unconjugated benign bilirubinemia is hyperbilirubinemia hemolysis or structural liver injury.

TREATMENT

Prevention and treatment options include:

  • Serial clinical examination of TB/TcB, its rate of increase and decrease as shown on the hour-specific bilirubin nomogram
  • To enhance milk transfer to the infant, enteral nutritional assistance is given.
  • Use of effective phototherapy.
  • A newborn intensivist may do a double volume exchange transfusion.
  • The use of chemoprevention with intravenous immune globulin (IVIG) in specific immune-hemolytic diseases among babies at risk for exchange transfusion in some infants and with a consultation.

Furthermore, treatment may vary, depending on your symptoms, underlying conditions, and present medications that you may take. Hence, it is important to coordinate with your doctor before receiving any medical treatment.

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