UMECLIDINUM BROMIDE VILANTEROL

Umeclidinium is a long-acting quaternary ammonium antimuscarinic substance. It intensely and reversibly hinders acetylcholine binding at type 3 muscarinic (M3) receptors in the bronchial smooth muscles, thus causing bronchodilation.

Vilanterol is a specific, long-acting β2-adrenergic agonist. It stimulates the release of cyclic adenosine-3′,5′- monophosphate (cAMP) by initiation of adenyl cyclase which results in the relaxation of bronchial smooth muscle.

Uses

Umeclidinum Bromide Vilanterol is used in the following:

Maintenance therapy in chronic obstructive pulmonary disease (COPD)

Warnings

Do not give Umeclidinum Bromide Vilanterol to people with the following conditions:

Asthma
Acute episodes of bronchospasm
Acutely deteriorating COPD
Concomitant use with other long-acting beta-2-agonists

Side Effects

Umeclidinum Bromide Vilanterol may have the following side effects:

Hypersensitivity reactions (e.g. anaphylaxis, angioedema, rash, urticaria)
Increased blood pressure and tachycardia
Atrial fibrillation
Hyperglycaemia
Diabetes mellitus and ketoacidosis exacerbation
Hypokalaemia
Urinary retention
Narrow-angle glaucoma
Bladder outlet obstruction
Central nervous system stimulation/excitation
Thyrotoxicosis exacerbation
Gastrointestinal disorders
Constipation
Dry mouth
Diarrhea
Abdominal pain
Nausea
Toothache
Musculoskeletal and connective tissue disorders
Muscle pain
Pain in extremity
Neck pain
Nervous system disorders
Headache
Vertigo
Tremor
Dysgeusia
Urinary tract infection
Thoracic and mediastinal disorders
Sinusitis
Nasopharyngitis
Pharyngitis
Upper respiratory tract infection
Cough
Pleuritic chest pain

Precautions

Precautions

Take extra caution in patients with the following medical conditions:

Patient with heart disease (e.g. cardiac insufficiency, arrhythmias, hypertension)
Diabetes mellitus
Narrow-angle glaucoma
Hypokalaemia
Prostatic hyperplasia/bladder neck obstruction
Seizure disorders
Thyrotoxicosis
Concomitant use with other long-acting muscarinic antagonists
Pregnancy and lactation

Interactions

Umeclidinum Bromide Vilanterol may interact with the following medicines:

Other anticholinergic drugs.
Strong CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin)
Methylxanthine derivatives
Steroids
Non-potassium-sparing diuretics
Beta-adrenergic blockers.
Monoamine oxidase inhibitors(MAOIs)
Tricyclic anti-depressants
Long-acting beta 2-adrenergic agonists (e.g. formoterol, salmeterol)

Overdose & Brands

If you think you may have used Umeclidinum Bromide Vilanterol more than the usual dose, seek medical help immediately.

Available Brands:

Anoro Ellipta