TRANDOLAPRIL

COMMON BRAND NAME(S): Mavik

GENERIC NAME(S): TRANDOLAPRIL

 

Description: Trandolapril, a prodrug of trandolaprilat, competitively inhibits ACE from converting angiotensin I to angiotensin II (a potent vasoconstrictor) resulting in vasodilation and BP reduction.

Onset: 1-2 hr.

Duration: At least 24 hr.

Pharmacokinetics:

Absorption: Rapidly absorbed. Bioavailability: 40-60% (trandolaprilat); 10% (trandolapril). Time to peak plasma concentration: 4-6 hr (trandolaprilat).

Distribution: Volume of distribution: Approx 18 L. Plasma protein binding: >80% (trandolaprilat).

Metabolism: Hepatically hydrolysed to trandolaprilat (active metabolite) and inactive metabolites.

Excretion: Via urine (approx 33%, as trandolaprilat); faeces (66%). Half-life: 16-24 hr (trandolaprilat).

Trandolapril, an ACE inhibitor that widens blood vessels through relaxation, treats high blood pressure (hypertension). This medication is also used to improve survival after an acute heart attack and with other drugs (e.g., “water pills”/diuretics, digoxin) to treat congestive heart failure. This medication may also be used to help protect the kidneys from damage due to diabetes.

How to use trandolapril

Take this medication by mouth, usually once or twice a day; or as directed by your doctor. You may take this drug with or without food. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time(s) each day.

The dosage is based on your medical condition and response to therapy. For the treatment of high blood pressure, it may take 1 week before the full benefit of this drug occurs or several weeks to months when used for congestive heart failure.

It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy.

Notify your doctor or pharmacist promptly if any of these effects persist or worsen:

  • dizziness
  • light-headedness
  • diarrhea
  • dry cough
  • blurred vision

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • fainting
  • decreased sexual ability
  • symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat)
  • change in the amount of urine
  • signs of infection (e.g., fever, chills, persistent sore throat)

This drug may rarely cause serious (possibly fatal) liver problems.

A serious allergic reaction to this drug is unlikely.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions:

  • Allergic reaction to this medication.
  • Patients with medical history of:
    • liver disease
    • high blood levels of potassium
    • severe dehydration (and loss of electrolytes such as sodium)
    • blood vessel disease (e.g., collagen vascular diseases such as lupus, scleroderma)
    • allergic reaction which included swelling of the face/lips/tongue/throat (angioedema)
  • May make you dizzy.
  • May increase your potassium levels.
  • Tell your doctor or dentist that you are taking this medication before having surgery.
  • Older adults may be more sensitive to dizziness and increases in potassium level.
  • This medication is not recommended for use during pregnancy.
  • Consult your doctor before breast-feeding.

Consult your doctor regarding the precautions mentioned above.

Interactions:

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of:

  • Aliskiren
  • drugs that suppress the immune system (e.g., azathioprine, everolimus)
  • lithium
  • gold injections
  • drugs that may increase the level of potassium in the blood (such as ARBs including losartan/valsartan, birth control pills containing drospirenone)

A very serious reaction may occur if you are getting injections for bee/wasp sting allergy (desensitization) and are also taking trandolapril.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose:

If overdose is suspected, contact a poison control center or emergency room immediately. Symptoms of overdose may include: unusually fast or slow heartbeat, severe dizziness, or fainting.

Notes

Do not share this medication with others. Lifestyle changes such as stress reduction programs, exercise and dietary changes may increase the effectiveness of this medicine. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.

Laboratory and/or medical tests (e.g., kidney function, potassium blood level) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Check your blood pressure regularly while taking this medication, especially when you first start this drug or when your dose is changed. Learn how to monitor your own blood pressure at home, and share the results with your doctor.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store the US product at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store in the bathroom.

Store the Canadian product at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture. Do not store in the bathroom.

Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Brands:

There are no brands containing this molecule.

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