COMMON BRAND NAME(S): Fareston
GENERIC NAME(S): TOREMIFENE CITRATE
Description: Toremifene, a non-steroidal triphenylethylene derivative, blocks the growth-inducing effect of oestrogen by competing with its binding sites.
Absorption: Well absorbed from GI tract. Peak plasma concentrations within 3 hr.
Distribution: Protein-binding: Extensive, mainly to albumin.
Metabolism: Metabolised mainly by the cytochrome P450 isoenzyme CYP3A4 to less active metabolites.
Excretion: Excreted mainly in faeces and in urine (10%) as metabolites. Undergoes enterohepatic circulation.