TIZANIDINE

Tizanidine is a TCA that is used as a muscle relaxant. It is a centrally acting α₂ adrenergic agonist. It reduces spasticity by increasing presynaptic inhibition of motor neurons and has no direct effect on skeletal muscle, the neuromuscular junction or on monosynaptic spinal reflexes.

Uses

This drug is used in treating muscle spasms caused by some conditions (like multiple sclerosis, spinal cord injury). It works by helping to relax the muscles.

Warnings

Do not use in patients with severe hepatic dysfunction.

Side Effects

Tizanidine can give rise to side effects such as:

Dry mouth
Drowsiness
Dizziness
Lightheadedness
Constipation
Weakness
Tiredness

Precautions

Precautions

Use with precaution in the following conditions:

Hepatic or renal insufficiency
Children, elderly
Pregnancy and lactation

Monitor liver function tests regularly. Stop its treatment if the liver enzymes are raised persistently >3 times the upper limit of normal range. Avoid abrupt withdrawal of therapy.

Interactions

Tizanidine may interact with the following medications:

Antihypertensives
Alcohol and CNS depressants
β-blockers and digoxin
CYP1A2 inhibitors e.g. zileuton, ciprofloxacin and other fluoroquinolones, antiarrhythmics, cimetidine, famotidine, oral contraceptives, aciclovir and ticlopidine
Rifampicin
Drugs that may prolong QT interval

Overdose & Brands

Symptoms of overdose may include:

Severe dizziness/drowsiness
Confusion
Slow/shallow breathing
Fainting

Available Brand:

Sirdalud