Tizanidine is a TCA that is used as a muscle relaxant. It is a centrally acting α₂ adrenergic agonist. It reduces spasticity by increasing presynaptic inhibition of motor neurons and has no direct effect on skeletal muscle, the neuromuscular junction or on monosynaptic spinal reflexes.

This drug is used in treating muscle spasms caused by some conditions (like multiple sclerosis, spinal cord injury). It works by helping to relax the muscles.

Do not use in patients with severe hepatic dysfunction.

Tizanidine can give rise to side effects such as:

  • Dry mouth
  • Drowsiness
  • Dizziness
  • Lightheadedness
  • Constipation
  • Weakness
  • Tiredness


Use with precaution in the following conditions:

  • Hepatic or renal insufficiency
  • Children, elderly
  • Pregnancy and lactation

Monitor liver function tests regularly. Stop its treatment if the liver enzymes are raised persistently >3 times the upper limit of normal range. Avoid abrupt withdrawal of therapy.



Tizanidine may interact with the following medications:

  • Antihypertensives
  • Alcohol and CNS depressants
  • β-blockers and digoxin
  • CYP1A2 inhibitors e.g. zileuton, ciprofloxacin and other fluoroquinolones, antiarrhythmics, cimetidine, famotidine, oral contraceptives, aciclovir and ticlopidine
  • Rifampicin
  • Drugs that may prolong QT interval

Symptoms of overdose may include:

  • Severe dizziness/drowsiness
  • Confusion
  • Slow/shallow breathing
  • Fainting


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