TEMSIROLIMUS - Uses, Warnings,Side Effects,Precautions,Overdose,


Temsirolimus is a protein based, mammalian target of rapamycin (mTOR) kinase blocker that regulates cell division. It prevents angiogenesis and suppresses tumour cell proliferation, growth and survival by binding to intracellular protein FKBP-12 creating a complex that hinders the mTOR stimulation.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully. 

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages. 

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day. 

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions. 

If you have any inquiries with regards to information, ask your physician or pharmacist.

Temsirolimus is used in the following conditions:

  • Advanced renal cell carcinoma
  • Relapsed or refractory mantle cell lymphoma 

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

  • Do not use Temsirolimus in people with the following conditions:
    • Hypersensitivity to temsirolimus and sirolimus. 
    • Moderate to severe hepatic impairment. 
    • Pregnancy and lactation. 
    • Concomitant administration of live vaccines.

Temsirolimus may have the following side effects:

  • Hyperglycaemia
  • Anaemia 
  • Neutropenia
  • Thrombocytopenia
  • Impaired wound healing
  • Cataracts
  • Increased cholesterol and triglycerides
  • Conjunctivitis
  • Abdominal distension or pain
  • Constipation
  • Diarrhoea
  • Nausea
  • Vomiting
  • Stomatitis
  • Gastritis
  • Gastrointestinal haemorrhage
  • Dysphagia
  • Gingivitis
  • Asthenia
  • Fatigue
  • Pain
  • Pyrexia
  • Chills
  • Oedema
  • Bacterial and viral infections
  • Increased creatinine
  • Decreased appetite
  • Dehydration
  • Diabetes mellitus
  • Hypokalaemia
  • Hypocalcaemia
  • Hypophosphatemia
  • Arthralgia
  • Myalgia
  • Back pain
  • Headache
  • Dizziness
  • Paraesthesia
  • Dysgeusia
  • Ageusia
  • Insomnia
  • Anxiety
  • Depression
  • Somnolence
  • Candidiasis
  • UTI
  • Pharyngitis
  • Rhinitis
  • Sinusitis
  • Epistaxis
  • Cough
  • Folliculitis
  • Rash
  • Dermatitis
  • Acne
  • Nail disorder
  • Ecchymosis
  • Petechiae
  • Pruritus
  • Hypertension
  • Thrombophlebitis
  • Venous thromboembolism

Potentially Fatal: 

  • Hypersensitivity/infusion reactions (including anaphylaxis, chest pain, dyspnoea, flushing)
  • Bowel perforation
  • Opportunistic infections (e.g. Pneumocystis jiroveci pneumonia) or sepsis
  • Interstitial lung disease
  • Intracerebral bleeding
  • Acute renal failure

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing. 

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Patient with diabetes
  • Hyperlipidemia
  • Central nervous system metastases/tumour
  • Risk factors for skin cancer
  • Patients taking strong CYP3A4 inhibitors or inducers
  • Perioperative period
  • Mild hepatic and severe renal impairment

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.



Temsirolimus may interact with the following medicines:

  • CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenytoin)
  • CYP3A4 inhibitors (e.g. clarithromycin, ritonavir, ketoconazole) 
  • Anticoagulants
  • Sunitinib
  • ACE inhibitors or Ca channel blockers.
  • Potentially Fatal: May diminish the therapeutic effect of live vaccines.


Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins. 

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details. 

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking. 

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If an overdose is suspected, call your health care provider immediately.


Available Brands:

  • Torisel

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