HUMAN PAPILLOMAVIRUS 9-VALENT VACCINE

TEGAFUR + GIMERACIL + OTERACIL

Tegafur, a fluoropyrimidine antimetabolite agent, is a prodrug of 5-fluorouracil that produces 5-fluoro-deoxyuridine-monophosphate as an active metabolite (FdUMP). FdUMP and decreased folate create a ternary complex with thymidylate synthase, which inhibits DNA synthesis.

Gimeracil increases 5-FU exposure and anti-tumor action by inhibiting dihydropyrimidine dehydrogenase (DPD), the major enzyme that degrades 5-FU.

Oteracil inhibits orotate phosphoribosyltransferase (OPRT), an enzyme hypothesized to be involved in 5-FU toxicity in the GI tract, lowering 5-FU toxicity in the GI mucosa.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist. 

Tegafur + Gimeracil + Oteracil is used in the following conditions:

  • Gastric cancer

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Tegafur + Gimeracil + Oteracil  in people with the following conditions:

  • Fluoropyrimidine treatment that has caused severe and unexpected effects in the past
  • Deficiency in DPD
  • Neutropenia
  • Leukopenia
  • Thrombocytopenia
  • ESRD that requires dialysis
  • Lactation and pregnancy

Tegafur + Gimeracil + Oteracil may have the following side effects:

  • Dizziness
  • Headache
  • Fatigue
  • Asthenia
  • Musculoskeletal pain
  • Hearing impairment
  • Deafness
  • Vision disorders
  • Palmar-plantar erythrodysaesthesia syndrome
  • Rash
  • Pruritus
  • Hyperpigmentation
  • Dry skin
  • Alopecia
  • Mucosal inflammation
  • Pyrexia
  • Chills
  • Insomnia
  • Hypotension
  • Peripheral edema
  • Nausea
  • Vomiting
  • Anorexia
  • Dysgeusia
  • Stomatitis
  • Dry mouth
  • Flatulence
  • Dyspepsia
  • Abdominal discomfort
  • Dysphagia
  • GI inflammation
  • GI hemorrhage.
  • Dyspnea
  • Bone marrow suppression
  • Acute renal failure
  • Diarrhea
  • Dehydration
  • Electrolyte disturbance
  • Lacrimal disorders
  • Peripheral neuropathy
  • Dizziness
  • Headache
  • Fatigue
  • Asthenia
  • Insomnia
  • Hypotension
  • Peripheral edema
  • Epistaxis
  • Hiccups
  • Cough
  • Hyperbilirubinemia
  • Increased ALT and AST
  • Hyperuricemia
  • Weight Loss

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects. 

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Severe hepatic and renal impairment

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Tegafur + Gimeracil + Oteracil may interact with the following medicines:

  • Anticoagulants derived from coumarin
  • Clozapine
  • Cimetidine
  • Methotrexate
  • Nitroimidazoles
  • With CYP2A6 inhibitors and allopurinol, effectiveness is reduced. Phenytoin causes an increase in plasma levels and toxicity.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or maycause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Symptoms of overdose may include the following: 

  • Bleeding
  • Bone marrow depression
  • Respiratory failure
  • Nausea
  • Vomiting
  • Diarrhea
  • Mucositis
  • GI irritation

Seek medical help immediately.

Available Brands:

  • Teysuno and TS-1

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