TAPENTADOL

Tapentadol is a centrally-acting pain reliever that inhibits pain signals by binding to mu-opiate receptors in the brain and in the spinal cord. It is also said to inhibit norepinephrine reuptake to alter pain response.

Tapentadol is used in the treatment of moderate to severe acute pain, and in neuropathic pain associated with diabetic neuropathy.

Tapentadol should not be given to people with the following conditions:

  • Significant respiratory depression
  • Acute or severe bronchial asthma or hypercapnia
  • Known or suspected paralytic ileus
  • Acute intoxication with alcohol, hypnotics, centrally acting analgesics or psychotropic active substances
  • Concurrent or recent (within 2 weeks) therapy with MAOIs

Tapentadol may have the following side effects:

  • Nausea
  • Vomiting
  • Dizziness
  • Somnolence
  • Constipation
  • Pruritus
  • Dry mouth
  • Hyperhidrosis
  • Fatigue
  • CNS depression
  • Seizures
  • Orthostatic hypotension
  • Syncope
  • Respiratory depression

Precautions

Take extra precautions in patients with the following conditions:

  • Impaired respiratory function
  • Head injury
  • Brain tumours
  • Biliary tract disease (including acute pancreatitis)
  • History of seizure disorder
  • Moderate to severe liver impairment
  • Severe kidney impairment
  • Pregnancy and lactation

 

Interactions

Tapentadol may interact with the following medicines:

  • Drugs that enhance monoaminergic neurotransmission (e.g. TCAs, triptans, SSRIs, serotonin and norepinephrine reuptake inhibitors)
  • Benzodiazepines
  • Barbiturates
  • Antipsychotics
  • H1-antihistamines
  • Other opioids
  • Mixed μ-opioid agonists/antagonists (e.g. nalbuphine, pentazocine)
  • Partial μ-opioid agonists (e.g. buprenorphine)
  • Strong inhibitors of UGT1A6, UGT1A9 and UGT2B7 isoenzymes
  • Strong enzyme inducers (e.g. rifampicin, phenobarbital)
  • MAOIs

Symptoms of overdose include the following:

  • Vomiting
  • Miosis
  • CV collapse
  • Consciousness disorders up to coma
  • Convulsions
  • Respiratory depression and arrest

Seek medical help immediately

 

Available Brands:

  • Nucynta
  • Palexia
  • Tapal

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