TAMOXIFEN CITRATE Uses Warning Side effects Precautions Overdose & Brands-Watsons Health
Watsons Health

TAMOXIFEN CITRATE

Tamoxifen is a kind of hormone treatment used to treat breast cancer in both pre-menopausal (women who have not yet experienced the menopause) and post-menopausal women. It can likewise be taken by men who have breast cancer growth.

The hormone estrogen can enhance breast cancers to develop. Tamoxifen might be given if your breast cancer includes receptors inside the cell that binds to the hormone estrogen (known as estrogen receptor positive or ER+ breast cancer). Invasive breast cancers are determined for estrogen receptors with biopsy or after surgery. At the point when estrogen attaches to these receptors, it can enhance the cancer to develop.

Tamoxifen blocks the impacts of estrogen on these receptors. This prevents estrogen from making cancer cells develop.

Tamoxifen Citrate is used in the following:

Do not give Tamoxifen Citrate to people with the following conditions:

Tamoxifen Citrate may have the following side effects:

  • Fluid retention
  • Nausea
  • Skin rashes
  • Vaginal discharge
  • Menstrual irregularities up to suppression of menstruation in premenopausal women
  • Vagina bleeding
  • Hot flashes
  • Transient anemia
  • Hypercalcemia in patient with bony metastases particularly on initiation of therapy
  • Increased serum triglycerides
  • Ligh theadedness
  • Headache
  • Visual disturbance (partially reversible) due to cataracts
  • Corneal changes and/or retinopathy
  • Ischemic cerebrovascular events
  • Leg cramps
  • Thromboembolic events
  • Vomiting
  • Diarrhea
  • Constipation
  • Changes in liver enzyme levels
  • Fatty liver
  • Alopecia
  • Hypersensitivity reactions including rare reports of angioedema
  • Myalgia
  • Pruritus vulvae
  • Increase of uterine fibroids
  • Proliferative endometrial changes (endometrial neoplasia, hyperplasia andpolyps, and rarely, endometriosis)

Precautions

Take extra caution in patients with the following medical conditions:

  • Endometrial cancer and uterine sarcoma (mostly malignant mixed Mullerian tumours)
  • Concomitant use of potent CYP2D6 inhibitors (eg, paroxetine, fluoxetine, quinidine, cinacalcet or bupropion)
  • Lactation
  • Children

 

Interactions

Tamoxifen Citrate may interact with the following medicines:

  • Coumarin-type anticoagulants
  • Cytotoxic agents.
  • CCYP3A4 inducing agent such as rifampicin
  • Potent CYP2D6 inhibitors (eg, paroxetine, fluoxetine, quinidine, cinacalcet or bupropion).

Symptoms of overdose include the following:

  • ECG alterations (prolonged QT time)
  • Neurotoxicity (tremor, hyperreflexia, unsteady gait and vertigo)

Seek medical help immediately.

Available Brands:

Fenahex, Gyraxen, Tamoxen, Gynatam, Nolvadex-D, Tamimex-20, Tamoplex,

Xifen

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