TAMOXIFEN CITRATE

Tamoxifen is a kind of hormone treatment used to treat breast cancer in both pre-menopausal (women who have not yet experienced the menopause) and post-menopausal women. It can likewise be taken by men who have breast cancer growth.

The hormone estrogen can enhance breast cancers to develop. Tamoxifen might be given if your breast cancer includes receptors inside the cell that binds to the hormone estrogen (known as estrogen receptor positive or ER+ breast cancer). Invasive breast cancers are determined for estrogen receptors with biopsy or after surgery. At the point when estrogen attaches to these receptors, it can enhance the cancer to develop.

Tamoxifen blocks the impacts of estrogen on these receptors. This prevents estrogen from making cancer cells develop.

Uses

Tamoxifen Citrate is used in the following:

Adjuvant therapy following primary treatment of breast cancer

Warnings

Do not give Tamoxifen Citrate to people with the following conditions:

Hypersensitivity
Pregnancy

Side Effects

Tamoxifen Citrate may have the following side effects:

Fluid retention
Nausea
Skin rashes
Vaginal discharge
Menstrual irregularities up to suppression of menstruation in premenopausal women
Vagina bleeding
Hot flashes
Transient anemia
Hypercalcemia in patient with bony metastases particularly on initiation of therapy
Increased serum triglycerides
Ligh theadedness
Headache
Visual disturbance (partially reversible) due to cataracts
Corneal changes and/or retinopathy
Ischemic cerebrovascular events
Leg cramps
Thromboembolic events
Vomiting
Diarrhea
Constipation
Changes in liver enzyme levels
Fatty liver
Alopecia
Hypersensitivity reactions including rare reports of angioedema
Myalgia
Pruritus vulvae
Increase of uterine fibroids
Proliferative endometrial changes (endometrial neoplasia, hyperplasia andpolyps, and rarely, endometriosis)

Precautions

Precautions

Take extra caution in patients with the following medical conditions:

Endometrial cancer and uterine sarcoma (mostly malignant mixed Mullerian tumours)
Concomitant use of potent CYP2D6 inhibitors (eg, paroxetine, fluoxetine, quinidine, cinacalcet or bupropion)
Lactation
Children

Interactions

Tamoxifen Citrate may interact with the following medicines:

Coumarin-type anticoagulants
Cytotoxic agents.
CCYP3A4 inducing agent such as rifampicin
Potent CYP2D6 inhibitors (eg, paroxetine, fluoxetine, quinidine, cinacalcet or bupropion).

Overdose & Brands

Symptoms of overdose include the following:

ECG alterations (prolonged QT time)
Neurotoxicity (tremor, hyperreflexia, unsteady gait and vertigo)

Seek medical help immediately.

Available Brands:

Fenahex, Gyraxen, Tamoxen, Gynatam, Nolvadex-D, Tamimex-20, Tamoplex,

Xifen