Selexipag - Uses, Warnings, Side Effects, Precautions, Overdose, Brands


Selexipag is a selective non-prostanoid agonist of prostacyclin (IP) receptor, that stimulates the release of prostacyclin, which is responsible to induce peripheral and pulmonary vasodilation and decrease elevated pressure in the blood vessels that supply blood to the lungs. It is a potent vasodilator with anti-proliferative properties, anti-inflammatory, and anti-thrombotic effects that inhibits platelet aggregation.


Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Selexipag is used in the following conditions:


  • Pulmonary arterial hypertension


This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Selexipag in people with the following conditions/medication:


  • Severe chronic heart disease or unstable angina
  • Recent myocardial infarction within 6 months
  • Decompensated cardiac failure
  • Severe arrhythmias
  • Transient ischemic attack or recent stroke within 3 months
  • Congenital valvular defects
  • Concomitant use with strong CYP2C8 inhibitor
  • Severe hepatic impairment

Selexipag may have the following side effects:


  • Pulmonary veno-occlusive disease
  • Hypotension
  • Hyperthyroidism
  • Headache
  • Flushing
  • Diarrhea
  • Nausea
  • Vomiting
  • Decreased appetite
  • Abdominal pain
  • Nasopharyngitis
  • Nasal congestion
  • Decreased thyroid stimulating hormone
  • Decrease weight
  • Decreased hemoglobin
  • Anemia
  • Jaw pain
  • Limb pain
  • Myalgia
  • Arthralgia
  • Rash
  • Urticaria
  • Erythema

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:


  • Moderate hepatic impairment
  • Pregnancy and lactation


Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.




Selexipag may interact with the following medicines:


  • Increased serum concentration with strong CYP2C8 inhibitor
  • Decreased serum concentration with CYP2C8 inducers


Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you think you have used Selexipag more than the usual dosage, please seek medical help immediately.


Symptoms of overdose may include the following:


  • Mild transient nausea


Available Brands:


  • Uptravi


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