Saxagliptin + Metformin- Uses, Warnings, Side Effects, Precautions, Etc.

Saxagliptin + Metformin

Saxagliptin + Metformin is a combination drug that is composed of the diabetes drugs Saxagliptin and Metformin.

Saxagliptin is a drug that is used to treat Type 2 diabetes mellitus. It inhibits the enzyme dipeptidylpeptidase-4 (DPP-4) which inactivates incretin hormones. This results to an increase in incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)]. These hormones control glucose homeostasis by increasing insulin from pancreatic beta-cells and diminishing glucagon from pancreatic alpha-cells, thus decreasing glucose production in the liver.

Metformin is a biguanide drug that lessens glucose production in the liver by diminishing gluconeogenesis and glycogenolysis, diminishes intestinal absorption of glucose, and improves insulin sensitivity by enhancing take-up of glucose in the tissues.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Saxagliptin + Metformin is used in the following conditions:

  • Type 2diabetes mellitus

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Saxagliptin + Metformin in people with the following conditions:


  • Acute or chronic metabolic acidosis (e.g. diabetic ketoacidosis, lactic acidosis)
  • Diabetic pre-coma
  • Alcoholism or acute alcohol intoxication
  • Acute or chronic disease that may cause hypoxia (e.g. cardiac or respiratoryfailure, recent myocardial infarction, shock)
  • Conditions which may alter renal function (e.g. severe infection, dehydration)
  • Hepatic and severe renal impairment
  • Lactation
  • Intravascular administrationof iodinated contrast agents

Saxagliptin + Metformin may have the following side effects:


  • Bullous pemphigoid
  • Severe arthralgia
  • Hypoglycaemia
  • Heart failure
  • Acute pancreatitis
  • Vit B12 deficiency
  • Anaphylaxis
  • Angioedema
  • Exfoliative skin conditions
  • Headache
  • Dizziness
  • Gastroenteritis
  • Nausea
  • Vomiting
  • Constipation
  • Upper respiratorytract infection
  • Sinusitis
  • Nasopharyngitis
  • UTI
  • Acute renal failure
  • Myalgia
  • Rash
  • Dermatitis
  • Pruritus
  • Urticaria

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist

Take extra caution in patients with the following medical conditions:


  • Congestive heart failure
  • History of pancreatitis
  • Those who are exposed to stress
  • Infection
  • Fever
  • Trauma
  • Recent surgery
  • Not intended for the treatment of diabetic ketoacidosis or type 1 diabetes mellitus
  • Renal impairment (GFR 30-45 mL/min)
  • Pregnancy


Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.




Saxagliptin + Metformin may interact with the following medicines:


  • Thiazides and other diuretics
  • Corticosteroids
  • Phenothiazines
  • Thyroid products
  • Oral contraceptives
  • Sympathomimetics
  • Phenytoin
  • Nicotinicacid
  • Calcium channel blockers
  • Isoniazid
  • Rifampicin
  • Carbamazepine
  • Dexamethasone
  • Phenobarbital
  • Phenytoin
  • Sulfonylureas
  • Insulin
  • Ranolazine
  • Vandetanib
  • Dolutegravir
  • Cimetidine
  • Zonisamide
  • Acetazolamide
  • Dichlorphenamide
  • NSAIDs
  • ACE inhibitors
  • Angiotensin II receptor antagonists
  • Diuretics

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If overdose is suspected, call your health care provider immediately.

Available Brands:

  • Kombiglyze XR
  • Onglyza

Related Articles


Drotaverine is an antispasmodic medication that works through the interference of phosphodiesterase-IV which has a fast and specific action on [...]


Droperidol is a dopamine inhibitor which suspends the chemical receptor’s simulation in the postrema region. It has a vasodilator property [...]


Ustekinumab, a human monoclonal antibody that attaches to and blocks interleukins (IL)-12 and IL-23 cytokines. These interleukins (IL)-12 and IL-23 [...]