Sapropterin is an engineered type of tetrahydrobiopterin (BH4), an endogenous cofactor for phenylalanine hydroxylase (PAH). This PAH enzyme hydroxylates phenylalanine through an oxidative response to create tyrosine. PAH activity is missing or inadequate in patients with phenylketonuria. Sapropterin enhances the action of leftover PAH, thus improving normal phenylalanine metabolism and diminishing serum phenylalanine levels.
Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.
The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at the usual prescription dosages.
If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.
Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.
If you have any inquiries with regards to information, ask your physician or pharmacist.