Watsons Health

RIFAMPICIN ISONIAZID

Rifampicin Isoniazid is a combination drug that is composed of two drugs which treat tuberculosis, isoniazid and rifampicin.

Rifampicin is a derivative of rifamycin that hinders the formation of bacterial RNA by binding to RNA polymerase, further repressing the connection of the enzyme to the DNA, blocking RNA elongation and transcription. It has bactericidal activity against tubercle bacilli.

Isoniazid is a drug that is also used to treat tuberculosis. It inhibits the formation of the cell walls of the tubercle bacilli, further killing them.

Rifampicin Isoniazid is used in treating extrapulmonary tuberculosis.

Do not give Rifampicin Isoniazid to people with the following conditions:

  • Hypersensitivity to any of the rifamycins or to isoniazid
  • Patients with previous isoniazid-associated hepatic injury or other severe adverse reactions to isoniazid
  • Hepatic function Impairment
  • Hypersensitivity

Rifampicin Isoniazid may have the following side effects:

  • Flu-like syndrome
  • Hematopoietic reactions
  • Skin reactions
  • Gastrointestinal and hepatic reactions
  • Shortness of breath
  • Shock
  • Renal failure

Take extra caution in patients with the following medical conditions:

Interactions

Rifampicin Isoniazid may interact with the following medicines:

  • Paracetamol
  • Oral anticoagulants
  • Barbiturates
  • Benzodiazepines
  • Beta-blockers
  • Chloramphenicol
  • Clofibrate

Symptoms of overdose may include the following:

  • Fever
  • Loss of appetite
  • Malaise
  • Vomiting
  • Darkened urine
  • Yellowish discoloration of the skin and eyes
  • Pain or swelling of joints

Seek medical help immediately.

Available Brands:

  • Bifix
  • Duomax
  • Fixcom 2
  • Myrin
  • Rimactazid
  • CombiPack
  • Rifinah
  • Rifzin F

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